Information about Crizotinib

Generic Name : Crizotinib
Up-to-date prescription details regarding Crizotinib are provided here.

Pronunciation : kriz OH ti nib

Learn the correct pronunciation of the Crizotinib, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Therapeutic Classification : Kinase Inhibitors

Trade Names/Brand Names of Crizotinib

International :

Xalkori

Why is Crizotinib Prescribed? (Indications)

This medication is an anaplastic lymphoma kinase (ALK) inhibitor, prescribed for non-small cell lung cancer. It works by preventing the growth of cancer cells.

When should Crizotinib not be taken? (Contraindications)

None.

What is the dosage of Crizotinib?

PO- The recommended dose is 250 mg twice daily.

How should Crizotinib be taken?

It comes as a capsule to take by mouth, with or without food.

What are the warnings and precautions for Crizotinib?

• Caution should be exercised in patients with history of liver or kidney disease, vision problems, abnormal heart rhythm, prolonged QT syndrome, electrolyte imbalance, who are taking other medications, any allergy, during pregnancy and breastfeeding.

• It may cause dizziness, drowsiness, or blurred vision, do not drive a car or operate machinery while taking this medication.

• It may reduce platelet counts; avoid injury or bruising.

• Avoid contact with people who have infections that may spread to others.

• Rarely patient may develop with fatal inflammation of the lungs (pneumonitis) with the following symptoms: trouble in breathing, shortness of breath, cough, or fever. If it is so consult with your healthcare provider immediately.

What are the side effects of Crizotinib?

Most Common - Pneumonia, hypoxia, ARDS, difficulty in breathing, lung inflammation, and lung bleeding.
Eye - Vision disorder.
Gastrointestinal - Nausea, diarrhea, vomiting, constipation, esophageal disorder, abdominal pain, and mouth ulcer.
General - Fluid retention, fatigue, and chest pain/discomfort, fever.
Metabolic - Increase in liver enzyme, decreased appetite.
Musculoskeletal - Joint pain, back pain.
Central Nervous System - Dizziness, nerve disease, headache, taste disorder, sleeplessness.
Respiratory - Cough.
Skin - Rash.