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General Information on Crizotinib

Generic Name : Crizotinib

Pronunciation : kriz OH ti nib

Latest prescription information about Crizotinib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Kinase Inhibitors

Trade Names/Brand Names of Crizotinib

International- Xalkori.

Why is Crizotinib Prescribed? (Indications)

This medication is an anaplastic lymphoma kinase (ALK) inhibitor, prescribed for non-small cell lung cancer. It works by preventing the growth of cancer cells.

When should Crizotinib not to be taken? (Contraindications)

None.

What is the dosage of Crizotinib?

PO- The recommended dose is 250 mg twice daily.

How should Crizotinib be taken?

It comes as a capsule to take by mouth, with or without food.

What are the warnings and precautions for Crizotinib?

Caution should be exercised in patients with history of liver or kidney disease, vision problems, abnormal heart rhythm, prolonged QT syndrome, electrolyte imbalance, who are taking other medications, any allergy, during pregnancy and breastfeeding.

It may cause dizziness, drowsiness, or blurred vision, do not drive a car or operate machinery while taking this medication.

It may reduce platelet counts; avoid injury or bruising.

Avoid contact with people who have infections that may spread to others.

Rarely patient may develop with fatal inflammation of the lungs (pneumonitis) with the following symptoms: trouble in breathing, shortness of breath, cough, or fever. If it is so consult with your healthcare provider immediately.

What are the side effects of Crizotinib?

   Most Common : Pneumonia, hypoxia, ARDS, difficulty in breathing, lung inflammation, and lung bleeding.
   Eye : Vision disorder.
   Gastrointestinal : Nausea, diarrhea, vomiting, constipation, esophageal disorder, abdominal pain, and mouth ulcer.
   General : Fluid retention, fatigue, and chest pain/discomfort, fever.
   Metabolic : Increase in liver enzyme, decreased appetite.
   Musculoskeletal : Joint pain, back pain.
   Central Nervous System : Dizziness, nerve disease, headache, taste disorder, sleeplessness.
   Respiratory : Cough.
   Skin : Rash.

What are the other precautions for Crizotinib?

Avoid excess dosage.

What are the storage conditions for Crizotinib?

Store it at room temperature (20 to 25 C).

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