Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Suchitra Chari
Medically Reviewed by Suchitra Chari, M.S. M.Sc.
Last Updated on Dec 15, 2017
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General Information on Clove oil

Generic Name : Clove oil

Pronunciation : KL-OVE-oil

Latest prescription information about Clove oil. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Analgesics

Trade Names/Brand Names of Clove oil

India : 

Overview of Clove oil

Clove oil, with its principal constituent eugenol, is mainly used in dentistry as an analgesic to relieve dental pain.

Why is Clove oil Prescribed? (Indications)

Clove oil has been approved by the US Food and Drug Administration (FDA) for use in dentistry as an analgesic (for relief of dental pain), for its use in dental cements, as a fragrance in aromatherapy oils, in transdermal drug delivery systems and in food as a flavoring agent.

Clove oil is obtained by distillation of the flowers, stems and leaves of the clove tree. Its primary and bioactive constituent eugenol (constituting 49 - 87%) is well-known for its therapeutic properties and is widely used in dentistry as an analgesic for toothache, joint pain, and as a antispasmodic.

Clove oil has also been found to possess antimicrobial (works against several bacteria and fungal strains), antiviral, anticancer, antioxidant (a neuroprotective for the treatment of memory deficits caused by oxidative stress), anti inflammatory, insecticidal, antidiabetic and lipid lowering properties. 

When should Clove oil not to be taken? (Contraindications)

Clove oil is contraindicated in people who are hypersensitive to clove oil or eugenol.
Clove oil should not be used while teething.

What is the dosage of Clove oil?

Clove essential oil is generally regarded as a safe (GRAS) substance if used / consumed below the concentrations of 1500 mg/kg.
The World Heatlth Organization (WHO) has established the daily acceptable quantity of clove per day as 2.5 mg/kg of weight in humans.

How should Clove oil be taken?

Adults, the elderly and children over 2 years old can use clove oil for dental pain by applying a small amount on a cotton bud directly on the tooth cavity as required.

What are the warnings and precautions for Clove oil?

Not recommended for use in children under 2 years of age, pregnant women and nursing mothers due to lack of sufficient data
Since eugenol can slow down blood clotting, caution should be taken when using in people with bleeding disorders and while undergoing any surgeries
Caution should be taken if the patient is taking drugs, herbs, or supplements that also affect blood clotting

What are the side effects of Clove oil?

  Skin: Mild skin and mucous membrane irritation, contact dermatitis, inflammation of lips and mouth
  Blood: Blood clotting disorder
  Gastrointestinal: Liver damage

Adverse effects like coma, acidosis, generalized seizure, disordered blood clotting and acute liver damage have been observed in children under 2 years of age who have consumed 5-10 ml of clove oil.

What are the other precautions for Clove oil?

Ingestion of clove oil can cause adverse effects; this has been reported in children under 2 years of age
Using too much oil can make patients sensitive to it
Do not use for eyes, ears or nose
Avoid contact with the skin and gums; repeated use may cause gum damage
Clove oil or any of its components must not be used as an anesthetic for fish, especially for long exposures due to toxicity concerns for the fish and to humans consuming them

What are the Drug Interactions of Clove oil?

Since eugenol can slow down blood clotting, caution should be taken when used with other medications that also slow down the clotting; the combined effect would be increasing the chances of bruising and bleeding.
Examples of such medications are aspirin, clopidogrel, diclofenac, ibuprofen, naproxen, dalteparin, enoxaparin, heparin, warfarin , and others.

What are the storage conditions for Clove oil?

Store the clove oil below 25C tightly closed and protected from light.
The oil is usually available in an amber glass bottle.

Last Updated : 12/15/2017

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