Cisplatin - Indications, Dosage, Side Effects and Precautions

Information about Cisplatin

Generic Name : Cisplatin
Up-to-date prescription details regarding Cisplatin are provided here.

Pronunciation : sis' pla tin

Learn the correct pronunciation of the Cisplatin, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Therapeutic Classification : Chemotherapy

Trade Names/Brand Names of Cisplatin

India :

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International :

Platinol

Why is Cisplatin Prescribed? (Indications)

This medication is a platinum-based chemotherapy agent, prescribed for ovarian cancer, bladder cancer and metastatic testicular tumors either alone or with other medications. It stops cancer cell growth.

When should Cisplatin not be taken? (Contraindications)

Contraindicated in patients with hearing impairment, kidney impairment and hypersensitivity.

What is the dosage of Cisplatin?

Adult: IV- Metastatic ovarian cancer As monotherapy: 100 mg/m² per cycle, given as a single dose once every 4 week.
For combination therapy with cyclophosphamide: 75-100 mg/m² on day 1 of every 4-week cycle. Metastatic testicular tumors 20 mg/m²/day for 5 days per cycle. Advanced bladder cancer 50-70 mg/m² per cycle once every 3-4 week.

How should Cisplatin be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Cisplatin?

• Caution should be exercised in patients with history of bone marrow suppression, kidney or liver disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breast-feeding.

• Monitor complete blood counts, ear and neurological functions regularly while taking this medication.

• Patients may develop with increased risk of nephrotoxicity (kidney damage with irritation), drink adequate fluids to prevent damage.

• Avoid vaccination while taking this medication.

• It may develop new type of cancer; if you have any doubt consult with your doctor regarding this.

What are the side effects of Cisplatin?

Toxic effects - Nephrotoxicity (kidney damage) and ototoxicity (ear damage).
Severe effects - Stroke, heart attack, electrolyte disturbances and allergic reactions.
Gastrointestinal - Loss of appetite, nausea and vomiting.
ENT - Ringing in the ear, loss of hearing and deafness.