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Chlorpropamide - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Chlorpropamide

Generic Name : Chlorpropamide
Up-to-date prescription details regarding Chlorpropamide are provided here.
Pronunciation : klor proe' pa mide
Learn the correct pronunciation of the Chlorpropamide, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y42.3 | Therapeutic Classification : Antidiabetics

Trade Names/Brand Names of Chlorpropamide

India : 

International : 

Chlorformin, Diabinese, Glucamide

Why is Chlorpropamide Prescribed? (Indications)

This medication is a sulfonylurea antidiabetic drug, prescribed for type 2 diabetes. This medication helps to keep blood sugar levels under control.  

When should Chlorpropamide not be taken? (Contraindications)

Contraindicated in patients with type 1 diabetes and hypersensitivity.

What is the dosage of Chlorpropamide?

PO- The recommended initial dose is 250mg/day. It may be adjusted based on patient’s condition.

How should Chlorpropamide be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Chlorpropamide?

• Caution should be exercised in patients with history of heart, liver, kidney, thyroid, adrenal or pituitary disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breast feeding.

• It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid drinking alcoholic beverages and smoking while taking this medication.

• Avoid exposure to sunlight; otherwise it may lead to sunburn.

• It may cause low blood sugar with the following symptoms: weakness, fainting, anxiety, dizziness or drowsiness, if it is so consult with your physician.

• Follow proper diet and exercise program as directed by your physician.

What are the side effects of Chlorpropamide?

   Body as a Whole : Low blood sugar, Disulfiram-like
   Central Nervous System : Dizziness and headache.
   Gastrointestinal : Diarrhea, nausea, vomiting, loss of appetite and hunger.
   Liver : Jaundice.
   Skin : Itching and hives.
   Blood : Anemia and decrease in blood counts.

What are the other precautions for Chlorpropamide?

Avoid excess dosage.

What are the storage conditions for Chlorpropamide?

Store it at room temperature, and in an airtight container. Keep away from children.

Schedule : G
Drugs that are to be used only under medical supervision.
Last Updated : August 11, 2022
Learn more about Chlorpropamide's interaction with Alcohol

Chlorpropamide : Frequently Asked Questions

Q: When is the best time to take Chlorpropamide?

A:    It is best to take chlorpropamide once a day with breakfast. It is better to take the tablet at the same time every day(1 Trusted Source

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Q: Does Chlorpropamide cause hyponatremia?

A: Chlorpropamide can cause hyponatremia (low blood sodium) by enhancing the action of vasopressin in the kidney, causing water retention(2 Trusted Source
Chlorpropamide-induced ADH release, hyponatremia and central pontine myelinolysis in diabetes mellitus

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Q: Is Chlorpropamide safe in elderly patients?

A: Chlorpropamide may cause hypoglycemia as it has a very long duration of action. Thus, chlorpropamide is not recommended for elderly patients(3 Trusted Source

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Q: Does Chlorpropamide cause weight gain?

A:  Chlorpropamide can cause weight gain. While taking this medication, it is important to keep a close eye on your diet and engage in regular exercise. Skipping meals can result in very low blood sugar levels, leading to snacking or taking a lot of sugar(4 Trusted Source
Sulfonylureas and their use in clinical practice

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Q:  What should be avoided while taking Chlorpropamide?

A: Alcohol should be avoided while on chlorpropamide because it lowers blood glucose levels and interferes with diabetes treatment. Even small amounts of alcohol cause facial flushing in many diabetics who take chlorpropamide(5 Trusted Source
Chlorpropamide-alcohol flushing, aldehyde dehydrogenase activity, and diabetic complications.

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Medindia adheres to strict ethical publishing standards to provide accurate, relevant, and current health content. We source our material from reputable places such as peer-reviewed journals, academic institutions, research bodies, medical associations, and occasionally, non-profit organizations. We welcome and value audience feedback as a part of our commitment to health literacy and informed decision-making.
  • 1. Chlorpropamide - (https://medlineplus.gov/druginfo/meds/a682479.html)
  • 2. Chlorpropamide-induced ADH release, hyponatremia and central pontine myelinolysis in diabetes mellitus - (https://pubmed.ncbi.nlm.nih.gov/8928190/)
  • 3. Chlorpropamide - (https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/chlorpropamide)
  • 4. Sulfonylureas and their use in clinical practice - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548036/)
  • 5. Chlorpropamide-alcohol flushing, aldehyde dehydrogenase activity, and diabetic complications. - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1499738/)
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