Information about Buserelin

Generic Name : Buserelin
Up-to-date prescription details regarding Buserelin are provided here.

Pronunciation : bue-se-REL-in

Learn the correct pronunciation of the Buserelin, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y43.3 Therapeutic Classification : Chemotherapy

Trade Names/Brand Names of Buserelin

Bucel (5 mg) | Zerelin (1mg/mL) | Bucel (0.5 mg)

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International :

Suprefact CinnaFact, Metrelef

Why is Buserelin Prescribed? (Indications)

This medication is a gonadotropin-releasing hormone agonist, prescribed for prostate cancer and breast cancer. It controls the release of eggs from ovaries by stopping the production of natural hormones.

When should Buserelin not be taken? (Contraindications)

Contraindicated in patients with hormone-dependent tumors, pituitary adenoma, weight-related amenorrhoea (absence of menstrual period).

What is the dosage of Buserelin?

SC- Advanced prostate carcinoma- Initial: 500 mcg 8 hourly for 7 days. Maintenance: 200 mcg once daily. Depot 6.3 mg implant 8 weekly or 9.45 mg 12 weekly.
Pituitary desensitisation before ovulation induction with gonadotrophins- 200-500 mcg/day until pituitary downregulation occurs, usually for 1-3 week.
Pituitary desensitisation before ovulation induction with gonadotrophins- 150 mcg 4 times/day beginning on day 1 or day 21 of the menstrual cycle until pituitary downregulation occurs, usually for 1-3 weeks.
For nasal dosage forms: Adults: 200 micrograms (mcg) (2 sprays) into each nostril every eight hours.

How should Buserelin be taken?

It comes as a solution for injection to be administered by a healthcare provider under the skin.

What are the warnings and precautions for Buserelin?

• Caution should be exercised in patients with history of high blood pressure, diabetes, depression, polycystic ovarian disease, during pregnancy and breastfeeding.

• Avoid use of nasal decongestants before and at least 30 min after treatment.

• Men at risk from tumor flare.

What are the side effects of Buserelin?

Central Nervous System - Headache, lightheadedness, mood changes and nervousness.
Heart - Palpitations.
Skin - Pimples, dry skin, itching, allergic reactions, changes in scalp and body hair.
Musculoskeletal - Tumor flare (may manifest as increase in bone pain) and spinal cord compression.
Genitourinary - Women- Worsening of urinary tract symptoms, blood in urine, increase in menstrual bleeding, urinary obstruction, vaginal dryness, hot flushes, loss of libido and osteoporosis.
Men- Hot flushes, breast swelling, tenderness and sexual dysfunction.