• Bemiparin is a low molecular weight heparin and a commonly used anticoagulant having antithrombotic properties of reducing the formation of blood clots.
Bemiparin is used for the treatment of deep vein thrombosis with or without pulmonary (lung related) embolism, for the prophylaxis (prevention) of venous thromboembolism in both surgical and non-surgical patients, and for clot prevention in an extracorporeal system during dialysis for the kidneys.
• Bemiparin is contraindicated in patients with hypersensitivity.
• For treatment of deep vein thrombosis in adults is 5,000 IU, 7,500 IU or 10,000 IU administered by subcutaneous injection at the dose of 115 IU/ kg/day, once daily, for 7±2 days.
• To prevent blood clots in the veins after general abdominal surgery or orthopedic surgery is 2,500 IU/day and 3500 IU/day respectively administered by subcutaneous injection for 7 to 10 days post surgery.
• To prevent blood clots in non-surgical patients during the risk period is 2,500 IU/ day or 3,500 IU/day by subcutaneous route.
• To prevent clotting during dialysis 2,500 IU or 3,500 IU is usually administered by injecting one bolus dose.
• Bemiparin sodium is available as pre-filled syringes (2500 units/0.2 ml solution) given as subcutaneous injection.
• Do not administer by the intramuscular route.
• Due to the risk of hematoma during bemiparin administration, the intramuscular injection of other agents should be avoided.
• If purpura or painful erythematous blotches are reported with bemiparin, treatment should be discontinued immediately.
• Injection site reactions
• Allergic reactions
• Decrease in platelet levels rarely
• Bemiparin sodium is contraindicated in patients with diabetes, ocular problems, renal stones, bleeding disorders, heparin allergy, pancreatic disorders , liver disorders, peptic ulcer, and metabolic acidosis, who are going to undergo an operation due to injury in the eyes, ears, brain, nerves and spinal cord, and during cerebrospinal fluid sampling.
• Bemiparin sodium interacts with alcohol. Alcohol should not be consumed while receiving Bemiparin sodium therapy.
Chances of bleeding increases when bemiparin is given along with
• Oral anticoagulants like dipyridamole
• Non-steroidal anti-inflammatory drugs like acetylsalicylic acid, phenylbutazone, ibuprofen , indomethacin
• Systemic glucocorticoids or dextran
• Glycoprotein IIb/IIIa receptor antagonists or antiplatelet agents
• Store at below 30° C.
• Do not freeze.
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