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Azacitidine - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Azacitidine

Generic Name : Azacitidine
Pronunciation : ay-za-SYE-ti-deen
Latest prescription information about Azacitidine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.1 | Therapeutic Classification : Chemotherapy
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Trade Names/Brand Names of Azacitidine

International- Vidaza.
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Why is Azacitidine Prescribed? (Indications)

This medication is an antineoplastic agent, prescribed for blood cancer. It slows or stops the growth of cancer cells by killing abnormal cells in the bone marrow.
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When should Azacitidine not be taken? (Contraindications)

Contraindicated in patients with advanced liver cancer and hypersensitivity.

What is the dosage of Azacitidine?

SC/IV- First Treatment Cycle: The recommended starting dose is 75 mg/m2, daily for 7 days.
Subsequent Treatment Cycles: Cycles should be repeated every 4 weeks. The dose may be increased to 100 mg/m2.

How should Azacitidine be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein or large muscle.

What are the warnings and precautions for Azacitidine?

• Caution should be exercised in patients with history of kidney or liver problems, any allergy, who are taking other medication, elderly, children, during pregnancy and breastfeeding.

• It may cause dizziness, fainting, or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

• It may reduce platelet counts; avoid injury or bruising.

• Monitor liver, kidney functions, and blood cell counts regularly while taking this medication.

• Avoid contact with people who have infections.

What are the side effects of Azacitidine?

   Most Common : Nausea, anemia, decrease in blood cells, vomiting, pyrexia, diarrhea, injection site redness, constipation and skin discoloration.
  Blood: Anemia.
   Gastrointestinal : Abdominal tenderness, constipation, diarrhea, gum bleeding, loose stools, bleeding of mouth, nausea, vomiting and mouth ulcer.
   General : Chest pain, injection site bruising, redness, pain, pigmentation, itching, swelling; lethargy, uneasiness and fever.
   Infections : Pneumonia and upper respiratory tract infection.
   Metabolic : Loss of appetite.
   Musculoskeletal : Joint pain, chest wall pain and muscle pain.
   Central Nervous system : Dizziness, headache, anxiety and sleeplessness.
   Respiratory : Difficulty in breathing.
   Skin : Dry skin, discoloration, redness, rash, scar and hives.
   Heart : Blood clot, low blood pressure, and red spots.
  Miscellaneous: Tumor lysis syndrome, injection site necrosis and Sweet’s syndrome.

What are the other precautions for Azacitidine?

Avoid excess dosage.

What are the storage conditions for Azacitidine?

Store unreconstituted vials at room temperature (25ºC).



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