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Aprotinin - Indications, Dosage, Side Effects and Precautions

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Information about Aprotinin

Generic Name : Aprotinin
Pronunciation : a-proe-TYE-nin
Latest prescription information about Aprotinin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Hemostatic Agents
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Trade Names/Brand Names of Aprotinin

India : 

International : 

Emend,Trasylol
International-Trasylol
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Why is Aprotinin Prescribed? (Indications)

This product is derived from bovine lung tissue, which inhibits certain enzymes that increase the risk for bleeding. This medication is a protease inhibitor, prescribed for reducing blood loss and the need for blood transfusion in patients undergoing complex surgery, such as heart and liver surgery.  
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When should Aprotinin not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Aprotinin?

The 1ml initial (test) dose should be administered intravenously at least 10 minutes before the loading dose.
Adult: IV- 5 lac KIU (Kallikrein in activator unit) initially, followed by 2 lac KIU every 4 hour.

How should Aprotinin be taken?

It comes as a solution for injection, to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Aprotinin?

• Test dose is recommended to all patients to assess the risk of hypersensitivity.

Caution should be exercised in patients with history of heart surgery, liver or kidney disease, allergy, during pregnancy and lactation.

The loading dose should be given intravenously to patients in the supine position over a 20-30 minute period. Rapid intravenous administration can cause a transient fall in blood pressure.

Pediatric use is not recommended. Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication.

What are the side effects of Aprotinin?

  Body as a Whole: Fever, infection, chest pain, weakness, sepsis, death, multi-system organ failure, immune system disorder.
  Heart: Low blood pressure, fast heart rate, heart attack and heart failure.
  Gastrointestinal: Nausea, constipation, vomiting, liver failure, jaundice and diarrhea.
  Blood: Anemia.
  Metabolic: Increased liver enzyme level, high blood sugar, decreased potassium levels.
  Musculoskeletal: Any event.
  Central Nervous System: Confusion, agitation, anxiety and sleeplessness.
  Respiratory: Lung disorder, pleural effusion, difficulty in breathing, increased cough, asthma and shortness of breath.
  Skin: Rash, skin discolouration.
  Genitourinary: Abnormal kidney function, urinary retention and urinary tract infection.
  Potentially Fatal:: Fatal anaphylactic reactions.

What are the other precautions for Aprotinin?

It should not be used in neonates and children.

What are the storage conditions for Aprotinin?

Store at 2-25C. Avoid freezing.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.



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