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Anastrozole - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Anastrozole

Generic Name : Anastrozole
Pronunciation : an as' troe zole
Latest prescription information about Anastrozole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y42.6 | Therapeutic Classification : Hormones
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Trade Names/Brand Names of Anastrozole

India : 

International : 

rimidex
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Why is Anastrozole Prescribed? (Indications)

This medication is a non-steroidal inhibitor used with other treatments, such as surgery or radiation, to treat early breast cancer in women who have experienced menopause. This medication is also used in women, who have experienced menopause, as a first treatment of breast cancer that has spread within the breast or to other areas of the body. It is also used to treat breast cancer in women whose breast cancer has worsened after taking tamoxifen (Nolvadex).  
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When should Anastrozole not be taken? (Contraindications)

Contraindicated in pregnant women, premenopausal women, patients who are experienced with hypersensitivity to any components.

What is the dosage of Anastrozole?

Adjuvant treatment in early breast cancer; Advanced or locally advanced breast cancer in postmenopausal women: 1 mg/day.

How should Anastrozole be taken?

This medication is available in the form of tablets to take by mouth once a day, with or without food.

What are the warnings and precautions for Anastrozole?

• Caution should be exercised in patients with history of moderate or severe liver impairment, excess fat, children.

• Be sure to mention any of the following: medications that contain estrogen such as hormone replacement therapy (HRT) and hormonal contraceptives (birth control pills, patches, rings, and injections); raloxifene (Evista); and tamoxifen (Nolvadex) before starting therapy with Anastrozole.

• It may cause dizziness. Do not drive a car or operate machinery while driving this medication.

• Avoid alcohol consumption.

• Do the lab test for menopause if status is doubtful.

• Bone mass density (bone mineral density) test should be conducted at the start of the therapy and at regular intervals thereafter.

What are the side effects of Anastrozole?

  Heart: Widening of blood vessels, hypertension, sudden cardiac death, blood clot in veins and insufficient blood supply to brain.
  Central Nervous System: Lack of energy, mood disturbances, headache, depression, sleeplessness, dizziness, fainting, abnormal sensations, anxiety, increased tightness of muscle, slurred speech and fatigue.
  Skin: Rash, sweating, redness of the skin, pain, burning, or tingling in the hands or feet, mucous membrane infection, hair thinning.
  Eye and ENT: Inflammation of pharynx, difficulty swallowing or breathing, persistent cough and clouding of eye lenses.
  Gastrointestinal: Stomach disturbances, nausea, loss of appetite, vomiting, abdominal pain, constipation, diarrhea, indigestion, gastrointestinal disorder and dry mouth.
  Genitourinary: Breast pain, urinary tract infection, inflammation of vagina, breast neoplasm, vaginal bleeding, whitish or yellowish vaginal discharge and vaginal dryness.
  Blood-Lymphatic: Lymph nodes swelling, decrease in hemoglobin, and white blood cells.
  Liver: Increased level of liver enzymes and jaundice.
  Hypersensitivity: Allergic reactions including hypersensitivity reaction, rapid swelling of the dermis and skin rash.
  Metabolic-Nutritional: Edema, high blood cholesterol, increased levels of alkaline phosphatases and weight loss.
  Musculoskeletal: Inflammation of joints, joint pain, back pain, bone pain, an increased risk of fracture, pelvic pain and muscle pain.
  Respiratory:Difficulty in breathing, increased cough, sinus or sinusitis and inflammation of bronchus.
  Miscellaneous: Bone weakness, hot flashes, pain, accidental injury, infection, chest pain, flu syndrome, cyst, neoplasm and tumor flare.

What are the other precautions for Anastrozole?

Monitor cholesterol levels and bone mineral density periodically.

What are the storage conditions for Anastrozole?

Oral: Store at 20-25°C. Store it in airtight container.



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Comments

mclen, India

since the cost of medication is so high foa a middle class person, can you suggest an equivalent for "ARMIDEX 1 mg" and the possible sources where it can be picked up at a discount?

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