Amifampridine is prescribed for treating muscle disorders such as Lambert-Eaton myasthenic syndrome (LEMS) among adults. This is a rare autoimmune disease. 

1.      Hypersensitivity to Amifampridine or Aminopyridine
2.      History of seizures

The recommended initial dose is 15 mg to 30 mg daily in divided doses (3 to 4 times daily).
Starting dosage is 15 mg daily for patients with renal impairment, hepatic impairment.
The dose can be raised by 5mg every 3 to 4 days. The maximum single dose is 20mg.

In case of missing the dose, patients should not take double or extra doses.

Amifampridine is available as a 10mg tablet to be taken orally.

1. General: Paresthesia, headache
2. Gastrointestinal: Nausea, diarrhea, abdominal pain, constipation
3. Respiratory: Upper respiratory tract infection
4. Vascular: Hypertension
5.  Muscles and Joints: Back pain, muscle spasms
6. Miscellaneous: Asthenia and cataract

1. Seizures: Amifampridine can cause seizures. Discontinue or reduce dose reduction in patients who have a seizure while on treatment.
2. If a hypersensitivity reaction like anaphylaxis occurs, the drug should be discontinued.
3. Liver enzymes may get increased. So frequent monitoring of liver function tests is recommended.
4. May harm developing fetus, if taken by pregnant women.

Amifampridine will interact with:
Drugs that lower seizure threshold
Drugs with cholinergic effects including direct or indirect cholinesterase inhibitors

Tablets: Store at room temperature 20-25o C
Excursions permitted from 15°C to 30°C