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Alfuzosin - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Alfuzosin

Generic Name : Alfuzosin
Pronunciation : al-fyu-zoe-sin
Latest prescription information about Alfuzosin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : BPH Agents
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Trade Names/Brand Names of Alfuzosin

India : 

International : 

Uroxatral
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Why is Alfuzosin Prescribed? (Indications)

Alfuzosin is used to treat an enlarged prostate or benign prostatic hyperplasia (BPH) symptoms in men by relaxing the muscles in the prostate and bladder neck and helps to urinate easily.

It is an alpha blocker helps to reduce the symptoms like difficulty with urination or incomplete emptying of the bladder in men.  
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When should Alfuzosin not be taken? (Contraindications)

Alfuzosin is contraindicated in patients who are allergic to the drug and with history of severe kidney or liver problems

What is the dosage of Alfuzosin?

Adult: The recommended oral dose is 10 mg to be taken once daily.

How should Alfuzosin be taken?

It comes as an extended release tablet to take by mouth, with food. The tablet should not be chewed or crushed.

What are the warnings and precautions for Alfuzosin?

• Caution should be exercised in patients with history of irregular heartbeat, prostate cancer, chest pain, low blood pressure, heart or kidney disease, any allergy, who are taking other medications and children.

• Alfuzosin is prescribed only for men .Women must not take this medicine especially during pregnancy and lactation.

• Avoid driving a car or operating machinery and get up slowly from bed while taking this medication as it may cause dizziness and lightheadedness.

• Avoid situations in which injury could occur because of fainting.

• Rarely, it may cause prolonged or painful erection; if so consult your doctor.

What are the side effects of Alfuzosin?

  Central Nervous System - Headache, dizziness and lack of energy.
  Heart - Low blood pressure, fainting, fast heart rate, chest pain and flushing.
  Gastrointestinal - Nausea, stomach pain, constipation
  Respiratory: Difficulty in breathing in case of allergic reaction, runny nose (rhinitis), cough and upper respiratory tract infections.
  Skin: Rashes and hives
  Genitourinary: Erectile dysfunction, painful erection and impotence
  Eye: Blurred vision; a condition called intraoperative floppy iris syndrome may occur in patients undergoing cataract surgery who were taking alfuzosin

What are the other precautions for Alfuzosin?

Avoid excess dosage. Alfuzosin does not cure the condition as a whole but provides relief and reduces the symptoms of benign prostate hyperplasia (enlarged prostate).
Do not consume grapefruit juice with alfuzosin to avoid possible side effects of the drug.
Inform the doctor before undergoing any dental or eye surgery, if you are taking alfuzosin.

What are the Drug Interactions of Alfuzosin?

Alfuzosin should be avoided with:
• Beta blockers like atenolol, metaprolol, nebivolol and propranolol, and other alpha blockers like doxazosin, prazosin, terazosin due to its additive effect resulting in low blood pressure.
• Anti-arrhythmic drugs like amiodarone, quinidine, procainamide, disopyramide, and dofetilide as it can lead to abnormal heart rhythms.
• Gastrointestinal drugs such as cimetidine, cisapride as these drugs reduce the metabolism of the drug and increase the levels of alfuzosin.
• Drugs used in the treatment of erectile dysfunction like sildenafil, vardenafil and tadalafil as they might severely lower the blood pressure and increase the side effects of the drug causing light headedness, dizziness, headache and nasal congestion.
• Protease inhibitors like indinavir, nelfinavir and lopinavir, antibiotics like clarithromycin and erythromycin and azole antifungals as that of ketoconazole and itraconazole slow down the metabolic process of alfuzosin in the liver thereby increasing the drug levels in the blood resulting in severe dizziness, fatigue and fainting.

What are the storage conditions for Alfuzosin?

Store it in a tightly closed container at room temperature. Protect from heat, light and moisture. Keep out of reach of children.
Last Updated : Jul 2018



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Comments

SSAhmad123, India

Dear Sir, Greetings of the day Myself is S S Ahmad. My age is 47 now and I have a problem of urine dripping [few drops] even after 10 to 15 minutes after passing the urine to its full extend. I am facing this problem since last 15 years. I told this problem to some doctors in the begining and I still remember that at that time one doctor advise me ultrasound and the radiologist who conducted ultrasound told me that about 20% urine remained to be discharge in the bladder but at that time the doctor told me that is normal and prescribed no medicine and no dietary or life style changes. Now recently I read some literature on this topic and came to know that it may be an indication of some problem in prostate gland. So I consulted the urologist and after going through the ultrasound and other tests the doctor has advised me table flotral 10 for three months. So I request you sir to kindly advise me what kind of dietary and life style changes are now required for me. Weather this problem will be solved permanently or not. I am worried kindly help me. Thanks S S Ahmad

mphawa1, India

sir, i am taking alfuzosin hcl [flotral 10 mg] for last 3years as prescribed by my doctor for my BPH problem of prostrate. But gradually i am finding it lesser effective. Further I am feeling that my digestive system gradually becoming weaker. I always have loose stool in the morning with out full satisfaction of defecation. Kindly advise if these are the side effects of prolonged use of this medication. I am 57 year male with BPH problem for last 10 years. Thanks, M.P. Hawa

drsan99, India

how long does it take to reverse the effect of Adura on libido

megs2202, India

Respected sir,
Myself Megha Shah student of B.M.Shah college of pharmaceutical education and research. i need Gift sample of ALFUZOSIN HCl (20 gm) for my M.Pharm thesis work. My thesis Title is DESIGN AND DEVELOPMENT OF ALFUZOSIN HCl FLOATING MICROSPHERES. i will be very thankful to you. i achknowledge you in my thesis work. kindly provide me as early as possible.
Your's Faithfully
Megha Shah
B.M.Shah college of pharmaceutical education and research
college campus
Dhansura road
modasa- 383315

angisri74, India

i had some urinary problem 1 year ago after taking alfusin i am ok . it is a good tablet



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