• Acebrophylline is used for its mucoregulative action and anti-inflammatory properties in the respiratory tract.
Acebrophylline is prescribed for its bronchodilator, mucolytic and anti-inflammatory action.
The combined action of ambroxol and theophylline 7-acetic acid salt (acebrophylline) reduces the viscosity of the mucus, relaxes the bronchial smooth muscles and enables the phlegm to get cleared from the respiratory tract.
It is used in the treatment of acute or chronic bronchitis, chronic obstructive pulmonary disease(COPD) and bronchial asthma.
• The recommended dosage for adults in treating COPD and bronchial asthma is 100 mg twice daily.
• Child dosage of acebrophylline syrup (50mg/5ml):
Below 2 years of age : 2.5 ml twice daily
2 - 5 years of age : 2.5ml three times daily
Above 5 years : 5 ml twice daily or as directed by the physician
• Acebrophylline is available in the form of a capsule, tablet and syrup.
• This drug should be taken orally with food to avoid gastric discomfort.
• Special precautions should be observed in patients suffering from seizures, cardiac insufficiency and gastro-intestinal disorders.
• Acebrophylline-induced angioedema, a serious allergic reaction, could occur
• Caution is advised in patients with hyperthyroidism, that is, high thyroid hormone levels since it can cause cardiac side effects
• Gastro-intestinal: Abdominal discomfort, esophageal bleeding, vomiting, diarrhea, constipation, loss of appetite
• Central Nervous System: Headache, drowsiness
• Respiratory: Difficulty or shortness in breathing
• Skin: Rashes, itching
• Others: Fever with chills, elevated white blood cell count, changes in blood pressure, numbness in the arm
• Avoid excess dosage.
Acebrophylline could be involved in the following drug interactions:
• Plasma concentration of acebrophylline may be increased with the concomitant administration of drugs like quinolones, cimetidine, erythromycin , oxytetracycline, lincomycin, and cephalexin
• Interaction with reserpine results in an increase in heart rate . Reserpine, though, is rarely used nowadays
• Barbiturates such as phenytoin may reduce the plasma concentration and therefore the effectiveness of acebrophylline
• Concomitant use with frusemide increases diuresis, as a result of which the patient will have to pass urine more often
• Acebrophylline can worsen low blood potassium levels caused by drugs like steroids
• Store in a cool, dry place. Protect from heat and moisture.
• Keep away from the reach of children.
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