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Abaloparatide - Indications, Dosage, Side Effects and Precautions

Last Updated on Jan 11, 2018
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Information about Abaloparatide

Generic Name : Abaloparatide
Pronunciation : a-BAL-oh-PAR-a-tide
Latest prescription information about Abaloparatide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Bone Enhancers
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Trade Names/Brand Names of Abaloparatide

Tymlos
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Why is Abaloparatide Prescribed? (Indications)

Abaloparatide is prescribed to treat osteoporosis in postmenopausal women who are at a high risk for fracture. It has a parathyroid hormone-related protein recommended when other drugs failed to treat osteoporosis. 
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When should Abaloparatide not be taken? (Contraindications)

Abaloparatide should not be used in patients with:

• Allergy to abaloparatide
• Bone-related disease such as Paget’s disease
• High levels of calcium or alkaline phosphatase in the blood
• Cancer of bone (osteosarcoma) or in patients at increased risk of the cancer
• Hyperactivity of parathyroid glands
• Pregnancy and breastfeeding mothers, premenopausal women
• Presence of high urinary calcium levels or calcium stones in the kidney

What is the dosage of Abaloparatide?

• The recommended adult dose is 80 mcg to be given subcutaneously (just under the skin) once a day.

How should Abaloparatide be taken?

• Abaloparatide injection comes as a solution in a prefilled pen which has to be given subcutaneously just under the skin directly into the periumbilical region (the region around the bellybutton) of the abdomen but 2 inches away from the bellybutton.
• The injection site should be rotated every day but has to be administered at the same time each day.
• The prefilled pen provides 30 doses offering a daily dose of 80 mcg of abaloparatide in a 40mcL of a sterile solution. The pen should be discarded after 30 days even if it contains some unused medication.
• The injection should not be administered either by intravenous (into the vein) or intramuscular route.

What are the warnings and precautions for Abaloparatide?

• The intake of too much alcohol or heavy smoking should be avoided because this leads to a reduction in bone mineral density resulting in more possible fractures.
• The use of abaloparatide and other parathyroid hormone analogs such as teriparatide for a period of more than two years is not recommended because of the risk of developing osteosarcoma.
• The patients should be given calcium and Vitamin D supplements if their dietary intake found to be inadequate.
• It is necessary to give first few doses of abaloparatide injection at a place where the patient can sit or lie down in case of orthostatic hypotension (low blood pressure in the standing position).
• Monitoring blood or urinary calcium levels must be carried out regularly in order to detect hypercalcemia, hypercalciuria or urolithiasis which are expected to occur in patients undergoing abaloparatide therapy.

What are the side effects of Abaloparatide?

  Gastrointestinal: Nausea, pain in upper abdominal area, constipation, upset stomach
  Cardiovascular: Orthostatic hypotension (sudden drop in blood pressure while standing), increase in heart rate, palpitations
  Central nervous system: Headache, dizziness, vertigo
  Genitourinary: Kidney stones, calcium loss in urine, blood in urine, pain while passing urine
  Skin: Pain, swelling or redness at the injection site
  Others: Immune-related allergic reactions, high blood calcium levels, tiredness, bone pain, increase in uric acid

What are the other precautions for Abaloparatide?

• Avoid injecting into the areas of bruised skin or red, scaly skin or in the area of scars or stretch marks.
• Before injecting, the pen it should be allowed to come to room temperature and should be discarded if visible particles are present or the solution appears cloudy.
• There is no specific antidote for abaloparatide poisoning but can be treated with appropriate measures such as discontinuation of the abaloparatide therapy hydration, and monitoring serum calcium and phosphorous levels.

What are the Drug Interactions of Abaloparatide?

• Not known.

What are the storage conditions for Abaloparatide?

• The unopened abaloparatide injection pen should be stored in the refrigerator between 2°C to 8°C but not in a freezer.
• After opening for first use, the injection can be stored at room temperature (20°C - 25°C) away from excess heat and moisture for a period of up to 30 days.
• Keep out of reach of the children.
Last Updated : Jul 2018



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