Tartarate Resistant Leukocyte Acid Phosphatase/ Acid phosphatase/ Leukocyte Acid Phosphatase. Indications :
This test is used to diagnose "hairy cell leukemia"/ "Leukemic reticuloendotheliosis"
There are six isoenzymes of leukocyte acid phosphatase. Isoenzyme V is not inhibited by L (+) tartaric acid. Malignant nuclear cells of leukemic reticuloendotheliosis contain isoenzyme V and are resistant to inhibition by L (+) tartaric acid. Normal Range :
Most white cells of peripheral blood as well as platelets are acid phosphatase positive.
Test Method :
Naphthol AS-BI, fast garnet GBC, with and without L(+) tartaric acid.Related Tests :
Leukocyte Cytochemistry, Lymph node biopsy