Hematology Test

Tartarate Resistant Leukocyte Acid Phosphatase/ Acid phosphatase/ Leukocyte Acid Phosphatase.

Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
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Test : Tartarate Resistant Leukocyte Acid Phosphatase/ Acid phosphatase/ Leukocyte Acid Phosphatase.

Indications : This test is used to diagnose "hairy cell leukemia"/ "Leukemic reticuloendotheliosis"

Physiology : There are six isoenzymes of leukocyte acid phosphatase. Isoenzyme V is not inhibited by L (+) tartaric acid. Malignant nuclear cells of leukemic reticuloendotheliosis contain isoenzyme V and are resistant to inhibition by L (+) tartaric acid.

Normal Range : Most white cells of peripheral blood as well as platelets are acid phosphatase positive.

Test Method : Naphthol AS-BI, fast garnet GBC, with and without L(+) tartaric acid.

Related Tests : Leukocyte Cytochemistry, Lymph node biopsy

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