Hematology Test

Sugar Water Test Screen/ PNH Test Screen/ Sucrose Hemolysis Test

Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
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Test : Sugar Water Test Screen/ PNH Test Screen/ Sucrose Hemolysis Test

Indications : The screening test for suspected paroxysmal nocturnal hemoglobinuria (PNH). Confirm the test with Ham Test.

Normal Range : If no hemolysis is present, the patient probably does not have PNH provided multiple recent transfusions have not reduced the proportion of abnormal cells.

Test Results : If the sugar water test is positive, a subsequent Ham test is strongly recommended. A negative sugar water test rules out PNH in most instances, provided the proportion of patient cells has not been reduced by previous transfusion. It has been demonstrated that the most complement sensitive cells in PNH are younger RBCs and reticulocytes. Increased sensitivity can be obtained for the assays by separating young RBCs from old by centrifugation.

Related Tests : Erythrocyte complement fixation Test,Ham Test

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