Indications : This test is used to diagnose hereditary spherocytosis, spontaneous hemolysis, RBC enzyme deficiency and hemolytic anemia.
Physiology : This test measures the degree to which patients red cells lyse without additives, with glucose and with ATP (Adenosine Tri-phosphate).
Interpretation : Glucose by itself can induce hemolysis in auto hemolysis test in patients with hereditary spherocytosis. Glucose-6-Phosphate dehydrogenase deficient RBCs have increased auto hemolysis, which corrects significantly with glucose or ATP. Pyruvatekinase deficiency has increased auto-hemolysis, which does not correct or get aggravated with glucose but does correct toward normal with ATP.
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