Test : Vitamin B12/ Anti-pernicious anemia factor/ Cyanocobalamin
Indications : The test is used to detect Vitamin B12 deficiency as in pernicious anemia in those patients who have hematologic symptoms – weakness, anemia, hyper-segmented neutrophils, leucopenia, or Neurologic – numbness, tingling, loss of vibratory sensation.
Physiology : Cyanocobalamin analogues from the base compound in coenzymes having important biologic functions. Vitamin B12 is not synthesized by humans. It is a requisite dietary component widely available in animal products. The minimum daily requirement is 1-5 µg/day, body stores are 2000-5000 µg. Vitamin B12 is absorbed by microvilli of the ileum a pH and divalent cation dependent process.
Normal Range : 100-250 pg/mL (74-185 pmol/L)
Click Here To View More Normal ValuesInterpretation : Vitamin B12 is low in hypochlorhydria, pernicious anemia, intestinal absorption, inflammatory bowel disease, bacterial infection. Diphyllobothrium fish tapeworm, intestinal surgery, oral contraceptives, increase in red blood cell volume. Vitamin B12 is increased in chronic granulocytic leukemia, chronic renal failure, severe congestive heart failure, diabetes, obesity and liver cell damage.
Test Method : Radioimmunoassay (RIA)
Related Tests : Complete Blood Count, Folic Acid, Hemoglobin, Intrinsic Factor Antibody, Red Blood Cell Indices, Schilling Test
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