Inherited Abnormalities of Platelet Production

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Condition	Abnormality
May-Hegglin	Severe thrombocytopenia
Wiskott-Aldrich	Severe thrombocytopenia with small platelets
Congenital thrombopoietin deficiency	Severe thrombocytopenia
Thrombocytopenia with absent radius	Moderate thrombocytopenia
Thrombasthenia	Absent clot retraction. Absent aggregation, mild thrombocytopenia
Bernard-Soulier Syndrome	Giant platelets, absent aggregation
Platelet Storage pool disease	Absent aggregation with collagen, mild thrombocytopenia, absent dense granules
Hermansky - Pudlak Syndrome	Aggregation abnormal with epinephrine and collagen, decreased dense granules and absent ADP stores
Release reaction abnormalities	Absent second wave aggregation with epinephrine and collagen, absent PF-3 release, varied inheritance.