► Delirium is a sudden severe state of confusion that is usually due to an illness.
► Stupor is a condition where the patient is unresponsive to normal stimuli but can be aroused by vigorous physical stimulation like excessive shaking or pinching.
► Coma is a state in which a person cannot be aroused even with vigorous stimuli.
► Persistent vegetative state is a condition where a person shows some improvement following a coma, and appears to lie motionless and without awareness and higher mental activity. It occurs when the brain hemispheres cannot work and the functions are taken over by the lower centers like the brainstem and the thalamus. These patients usually die after months or years, but rare cases of partial recovery have been encountered in clinical practice.
► Minimally conscious state is a condition where the patient exhibits inconsistent signs of consciousness. The patients show some degree of awareness of self and surrounding.
► Locked-in state is a condition where the patient is conscious and aware of the surroundings but unable to move. The patient can only respond by opening and closing the eyes.
► Brain death is a state where the patient suffers from irreversible coma with loss of ability to maintain body functions including breathing.
In cases where the cause can be reversed, the patient may recover completely if there is no accompanying brain damage. In some cases, the patient needs continuous ventilatory support.
A history obtained from the patient’s attendants often helps to diagnose the underlying cause of decreased consciousness. Some features that could help in the diagnosis are:
► A high temperature may indicate infection, heat stroke or drug overdose.
► Decreased consciousness in a diabetic may be due to a low or high blood sugar level.
► An abrupt decrease in consciousness could be due to a bleed in the brain or its immediate surrounding, or a brainstem stroke. A slower decrease could indicate a tumor.
► An abnormally low temperature may be due to prolonged exposure to cold, hypothyroidism, excessive alcohol or medication intake, or infection in older people.
► A metabolic cause should be suspected if the patient suffered from intoxication or agitated delirium before the decrease in consciousness.
► An absence of response to painful stimuli in one limb may indicate a problem in the brain. Absent responses of limbs on both sides could indicate that the brainstem is involved.
► Pinpoint pupils that respond to light may indicate opioid poisoning. Examination of eye movements helps to localize the site of the lesion.
Some of the tests that could assist in the diagnosis of the cause of decreased consciousness are:
► Blood tests: An abnormal liver or kidney function test may indicate liver or kidney failure, respectively. A low blood sugar level indicates hypoglycemia.
► A CT scan or MRI can detect brain tumors or structural damage to the brain.
► A spinal tap may show the presence of meningitis or a bleed around the brain.
Causes of Decreased Consciousness
Causes of decreased levels of consciousness are listed below:
Conditions that decrease oxygen, glucose or cofactors supply to the brain: Conditions that deprive the brain of its requirements to function properly result in an altered level of consciousness. These include:
► Alterations in glucose levels: High blood sugar levels can lead to diabetic coma. On the other hand, low glucose levels can lead to hypoglycemic coma. An altered level of consciousness in a diabetic should raise the suspicion of a problem in blood sugar level.
► Cardiac causes: A cardiac arrest results in a reduced supply of oxygen-rich blood to the brain. Other heart conditions like heart failure could cause similar problems. These conditions may be diagnosed with an ECG or other cardiac tests. Low blood pressure could also result in decreased blood supply to the brain.
► Lung diseases: Severe lung conditions like chronic obstructive pulmonary disease, pulmonary edema (fluid in the lungs), pulmonary embolism (a clot in the lungs), and severe and long-lasting asthma attacks can reduce oxygen content of the blood and thereby the supply to the brain and result in brain damage. A difficulty with breathing is usually obvious in these patients.
► Deficiency of B group of vitamins: A person with severe deficiency of vitamin B1 or thiamine suffers from beriberi, which sometimes causes confusion and delusions. Deficiency of the vitamin B3 or niacin results in pellagra, which is also associated with confusional states. In addition, the patient shows digestive problems and skin inflammation.
Metabolic, Hormonal and Other General Conditions: Metabolic conditions result in the accumulation of excessive or toxic substances in the blood resulting in decreased consciousness: Some of these conditions are listed below:
► Liver failure: Liver failure results in the accumulation of toxic substances in the body, which affect the brain and reduce consciousness, even leading to hepatic encephalopathy and coma. Other signs of liver failure may be present like accumulation of fluid in the abdomen and jaundice.
► Kidney failure: Kidney failure results in high levels of urea in the body, which could affect the level of consciousness. Other features of kidney failure may be present in these patients.
► Hypothyroidism: Very low or very high thyroid levels are associated with altered consciousness. Very low levels could result in a type of coma called myxedema coma.
► Hypothermia or hyperthermia: A change in temperature can affect the brain resulting in damage. High temperatures tend to affect the brain more as compared to lower temperatures.
► Abnormal sodium levels: High sodium levels in the blood, which is often a consequence of dehydration, can reduce consciousness. On the other hand, hyponatremia or low sodium levels could result in accumulation of fluid in the brain, again affecting the level of consciousness.
Drugs, Alcohol and Poisons: Consciousness could be affected by substances that act on the brain. A history of intake of these substances may be obtained from the patient’s relatives. Some of these are:
► Drugs: Drugs are often the cause of an altered level of consciousness in older individuals. This is especially in the case of drugs that act on the brain like sedatives and opioids. Older people are more sensitive to medications and often take multiple medications. Dosages if not reduced in these individuals can result in decreased consciousness. People who take drugs that could possibly reduce their level of consciousness are advised to avoid using machinery or drive to avoid accidents. They are also advised to avoid alcohol due to the additive effect in reducing brain function.
► Alcohol: Alcohol affects the brain in multiple ways. It can directly affect the brain cells causing them to function slowly. In addition, it can affect lung function and reduce the oxygen supply to the brain.
► Poisoning: Poisoning with carbon monoxide results in reduced oxygen-rich blood to the brain.
Conditions affecting the brain: Conditions that directly affect either both the cerebral halves of the brain or the reticular activating system of the brainstem (which is responsible for arousal) can result in reduced levels of consciousness. These conditions are diagnosed based on a detailed neurological examination and tests like CT scan and MRI. These conditions include:
► Stroke: A stroke can affect consciousness in a number of ways. It decreases blood supply to the areas of the brain involved in maintaining consciousness like the brainstem and the cerebrum. A bleed within or just outside the brain can exert pressure on the brain or result in irritation.
► Brain tumors / abscess: A brain tumor or abscess can occupy space within the skull and exert pressure on a part of the brain. In some cases, it can press on the brain excessively damaging it and even pushing it through some of the openings at the base of the skull. This situation is referred to as herniation of the brain, which can worsen the patient’s condition. The tumor may also directly affect the areas of the brain controlling consciousness. Breathing may be altered in these patients. Examination of the eyes helps in the diagnosis of these conditions.
► Aneurysms in the brain: An aneurysm is a swelling of a blood vessel of the brain. It could affect consciousness by exerting pressure on the brain or resulting in a bleed.
► Head injury: Head injury may damage the brain and cause loss of consciousness, sometimes even leading to coma. In some cases, the head injury results in a bleed within the skull. The bleed puts pressure on a part of the brain and can result in decreased consciousness.
► Seizures: Following a seizure, the patient sometimes goes into a deep sleep. This is referred to as the post-ictal stage.
► Infections: Infections of the brain called encephalitis, or the covering of the brain called meningitis can result in altered levels of consciousness. The neck of the patient may be rigid in cases of meningitis. Besides, sepsis may also affect the brain, altering the consciousness levels.
Frequently Asked Questions
1. Which doctors treat patients with decreased consciousness?
Patients with decreased consciousness are treated by a neurologist or a neurosurgeon.
2. How does an increase or decrease in blood glucose affect brain function?
A decrease in blood glucose levels deprives the brain of its nourishment. On the other hand, a high glucose level makes the blood hypertonic and dehydrates the brain of its water content, thus affecting the level of consciousness.
3. Is breathing affected in coma?
Breathing is often affected in coma with the breathing becoming too fast, too slow or too deep or irregular. The abnormal patterns of breathing may be repeated at regular intervals.
4. What is the Glasgow Coma scale?
The Glasgow Coma scale is a measure of the level of consciousness of a head-injury patient. It assesses the patient based on certain responses – eye opening, verbal response and motor response i.e. movement of limbs. A score of 3 to 8 indicates severe brain damage.
Latest Publications and Research on Decreased ConsciousnessClinical Case of Anti-N-methyl-d-aspartate Receptor Encephalitis in an 8-Month-Old Patient With Hyperkinetic Movement Disorder. - Published by PubMed
The exploratory burr hole: indication and results at one departmental hospital of benin. - Published by PubMed
The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines. - Published by PubMed
Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours. - Published by PubMed
Recovery of locked-in syndrome following liver transplantation with calcineurin inhibitor cessation and supportive treatment. - Published by PubMed