Whooping cough or pertussis is an acute respiratory tract infection caused by a bacterium called Bordetella pertussis, which causes uncontrolled episodes of persistent coughing. “Pertussis” also means “violent cough” and the Chinese call it “the cough of 100 days” because it lasts for a long duration.
In children, there is a sudden characteristic whooping sound while breathing in, following a coughing episode. This ‘whoop’ is however absent in adults and infants.
Facts about Whooping Cough:
► Whooping cough is prevalent in almost all countries especially the tropics.
► Children below 5 years are most affected which comprise of almost 90% of all cases. However, there is a recent increase in the adolescent age group.
► According to the Centers for disease control and prevention (CDC), the maximum number of whooping cough cases and half of the deaths due to whooping cough occur in children below 1 year.
► Whooping cough is a highly communicable disease with an attack rate of over 90%-100 % in non-immunized households.
► Whooping cough has a higher incidence in females with more fatality.
► Recovery from whooping cough or immunization helps to increase immunity. A mild second attack may occur in some cases..
► There is an increased incidence during winter and spring months due to overcrowding.
► There is also an increased incidence and exposure in a lower socioeconomic group because of living in unsanitary and overcrowded places.
► Whooping cough usually spreads by respiratory droplets infection from symptomatic infected individuals or by direct contact.
► The time for the disease to manifest once Bordetella pertussis infects a person ranges from 5-14 days but is usually 7-10 days.
► There is a steady increase in the cases of whooping cough globally especially in cases where there is no immunization.
The clinical course of the disease comprises of three stages, which are the catarrhal, the paroxysmal and the convalescent stages. The patient is diagnosed based on the clinical features and culture of bacteria from the nose and throat. Treatment includes antibiotics and supportive care. Whooping cough can be prevented by immunization with DPT vaccine.
Latest Publications and Research on Whooping CoughNew Brunswick government turns down pharmacists' offer to vaccinate against whooping cough. - Published by PubMed
A proteoliposome formulation derived from Bordetella pertussis induces protection in two murine challenge models. - Published by PubMed
Current controversies in childhood vaccination. - Published by PubMed
Quantification of the Adenylate Cyclase Toxin of Bordetella pertussis In Vitro and during Respiratory Infection. - Published by PubMed
Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: Comparison of three different vaccines and effect of a booster dose. - Published by PubMed