Walking Corpse Syndrome / Cotard's Syndrome was first described by Jules Cotard way back in 1880 as ‘délire des negations’ or negative deliriums.
Studies indicate that the disease is more prevalent in older patients with depression. It is also more likely to occur in patients with disorders like schizophrenia, bipolar disorders, brain injury, brain atrophy, seizure disorders, depression, brain tumors, stroke, migraine and in patients with delirious states. Women may be more commonly affected than men.
Though the exact cause is not known, lesions in frontal and temporal regions (front and sides) of the right hemisphere of the brain have been associated with the disease.
Some patients suffering from ‘Walking Corpse Syndrome’ have died of starvation since they deprived themselves of food thinking that they are already dead. The patients also have a tendency to attempt suicide and harm themselves.
The condition is diagnosed on the basis of symptoms of the patient. Tests are used to diagnose associated diseases and rule out other conditions. Current treatment involves medication with antidepressants, antipsychotics and mood stabilizers. Electroconvulsive therapy in combination with medications has been reported to be more effective than medications alone.
Causes and Risk factors of Walking Corpse Syndrome
Walking Corpse Syndrome occurs due to lesions in frontal and temporal regions of the right hemisphere of the brain.
The exact cause for ‘Walking Corpse Syndrome’ is not known. However, studies suggest that the cause is localized in the frontal and temporal regions of the right hemisphere of the brain.
Risk factors that have been associated with Cotard’s syndrome are-
► The condition is more common in older individuals with depressive disorders
► It is associated with other mental disorders like schizophrenia, bipolar disorders and dementia
► It has been associated with other conditions affecting the brain like brain atrophy, brain tumors, seizure disorders, brain injury, migraine, Parkinson's disease and stroke
► It could also be a consequence of an adverse drug reaction to acyclovir, an antiviral drug, in patients with kidney failure. These patients are unable to excrete a metabolite of acyclovir called CMMG, which accumulates in the blood and causes the symptoms
Signs and Symptoms of Walking Corpse Syndrome
People with ‘Walking Corpse Syndrome’ believe that they are dead.
Patients with ‘Walking Corpse Syndrome’ have a vague feeling of anxiety in the initial stages. This is followed by a belief that they are dead, do not exist, are putrefying (they can even smell rotting flesh) or have lost their vital organs. Some patients actually feel that they are immortal.
Clinical features include depression, feeling of guilt, negativity and insensitivity to pain. The patients may also believe that they are paralyzed or have auditory or smell-based hallucinations.
People affected by this disorder cannot recognize their own face and do not show any interest in social life or pleasure. They are always paranoid and neglect their own hygiene. They have a suicidal tendency or may harm themselves. They lose sense of reality and have distorted view of the world.
Yamada suggested a classification of Cotard's syndrome; he divided it into three stages based on the symptoms:
► Germination stage: In this stage, the patient shows characteristic features of depressive mood, extreme worry of unwellness and excessive fear of one’s illness, despite medical treatment.
► Blooming stage:In this stage, the patient experiences true features of the syndrome i.e. delusion of being dead or immortal; this stage is associated with anxiety and negativism.
► Chronic stage:In this stage, the individual shows severe depression due to emotional disturbances or paranoia.
Diagnosis of Walking Corpse Syndrome
‘Walking Corpse Syndrome’ is diagnosed based on the patient’s history and symptoms. Tests are used to exclude other conditions as well as to diagnose associated diseases. These tests include:
► Blood test
► CT Scan (Computed tomography)
► MRI (Magnetic Resonance Imaging)
► SPECT (Single-photon emission computed tomography)
► Electroencephalogram (EEG)
Treatment of Walking Corpse Syndrome
Walking Corpse Syndrome / Cotard's syndrome is treated with medications in combination with electroconvulsive therapy.
Treatment of ‘Walking Corpse Syndrome’ includes the following:
► Identification and treatment of risk factors: Risk factors for ‘Walking Corpse Syndrome’ should be identified and treated.
► Antidepressants, antipsychotics and mood stabilizer medications: Antidepressants, antipsychotics and mood stabilizers are used in the treatment of Cotard’s syndrome. Based on the underlying condition, the patient should be treated with a single drug or combination of medications. Mood stabilizers have beneficial effects in patients with bipolar disorder.
► Electroconvulsive Therapy: Many cases have shown that a combination of electroconvulsive therapy (ECT) with medications was more effective to manage the condition as compared to medications alone. ECT involves placing electrodes on the patient’s head and administering the small impulses.
Interesting Cases of Walking Corpse Syndrome
Some interesting cases of Walking Corpse Syndrome reported in medical literature are listed below:
A 53-year old Filipino woman was brought to a hospital when she complained that she was dead, smelled like rotting flesh, and wanted to be taken to a morgue to be with dead people. Upon questioning, she expressed fear that “paramedics” were trying to burn down her house. She also complained of hopelessness, low energy, decreased appetite, and excessive sleepiness. She responded to treatment with medications.
A patient who was taken to South Africa from Edinburgh after a period of hospitalization was convinced that he was taken to hell after his death. He believed that he had died of septicemia, AIDS or an overdose of yellow fever injection. He felt that it was not his mother who accompanied him, but her spirit.