Small Eye Syndrome - Causes, Symptoms, Diagnosis & Treatment

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Small Eye syndrome or Microphthalmia is a disorder in which one or both the eyes of the newborn baby are underdeveloped.

Small Eye Syndrome, medically known as Microphthalmia, is a condition observed in 11% of the blind children. It is a disorder in which one or both the eyes of the newborn baby are underdeveloped.

Small Eye Syndrome | Microphthalmia

The normal axial length of the eyeballs in neonatal and adult humans is approximately 17 and 23.8 mm, respectively. In this disorder, the eyeballs are abnormally smaller with an axial length of less than 21mm in adults. In the extreme conditions, one or both eyes are totally absent; this condition is known as anophthalmia.

Conditions that increase the risk of microphthalmia are maternal age more than 40 years, low birth weight and premature birth.

Causes of Small Eye Syndrome

Various genetic factors, which affect the early development of the eyes, are found to be responsible for this condition. Certain environmental factors may also contribute to the condition.

► Genetic Factors

Bullet The condition may be inherited from an affected parent through defective or mutated genes or chromosomes

Causes of Small Eye Syndrome: Mutated Genes

► Environmental Factors: Environmental factors that could result in the development of small eyes are:

Bullet Exposure to harmful chemicals and toxins during pregnancy

Bullet Exposure to harmful radiations like X-rays

Bullet Infections during pregnancy like rubella

Bullet Deficiency of vitamins during pregnancy especially vitamin A

Clinical Features of Small Eye Syndrome

► Children with microphthalmia present with visual disturbances and learning disabilities.

Bullet Children and adults may also have other problems like cataract (clouding of the eye lens), glaucoma (increased fluid pressure of the eye), and colobomas (missing pieces of the eye tissue).

Clinical Features of Small Eye Syndrome: Glaucoma

Diagnosis of Small Eye Syndrome

Small Eye Syndrome is diagnosed based on-

► Pre natal and post natal examination of the child. Measurement of corneal diameter also helps in the diagnosis.

► Imaging tests like ultrasonography, CT and MR scanning are used to study the size of the eyeball. Ultrasound can be used to diagnose the condition even before birth.

► Genetic analysis is done to detect any defective genes or abnormal chromosomes. The test can be done before birth as well.

Treatment of Small Eye Syndrome

Treatment of small eye syndrome is directed towards improving the existing vision in the affected eye by strengthening the eye tissues. This helps in preventing complete blindness to some extent. Early treatment intervention helps improve the overall eye development of the affected child.

► Surgery is usually recommended both for corrective and cosmetic purpose.

Treatment of Small Eye Syndrome: Surgery

► Prostheses are sometimes used to stimulate the growth of the socket. Patches may be used over the healthy eye to stimulate vision in the affected eye.
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