Intravenous antibiotics constitute the mainstay in the treatment of sepsis.
Patients with sepsis are serious cases and undergo treatment in a hospital or an intensive care unit (ICU). Treatment includes:
Antibiotics: Antibiotics should be administered into the vein soon after obtaining blood and tissue samples for culture. Initially, an antibiotic that is effective against a wide range of microorganisms is used. Once the culture report is obtained, the antibiotic may be changed to one which the microorganism is sensitive to.
Surgical removal or drainage of infected tissue: Any abscess which may be the source of infection should be drained and any infected tissue should be removed surgically.
Intravenous (IV) fluids: Intravenous fluids are used to maintain the blood pressure. Some patients may need the addition of drugs like dopamine to raise the blood pressure.
Ventilator Support: A decrease in respiratory function may necessitate the use of oxygen or ventilator support.

Other factors such as nutrition and glucose levels should be maintained.
A number of patients with septic shock do not survive despite treatment.