A patient with sclerosing cholangitis may show symptoms of fever, fatigue, weight loss, itching, jaundice and pain in the abdomen.
A patient with primary sclerosing cholangitis may not experience any symptoms or may complain of the following:

Fever

Fatigue

Weight loss

Itching

Jaundice

Pain in the abdomen

The patient may pass excessive fat in the stools leading to bulky, foul smelling stools
On examination, the spleen and/or liver may be enlarged. The skin may show darkening and scratch marks due to itching. The patient’s abdomen may appear bloated in severe cases due to accumulation of fluid.