Rickets / Paediatric Osteomalacia

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What are the causes of rickets?

The main cause of rickets is the deficiency of vitamin D caused in the body during childhood. Vitamin D is a fat-soluble vitamin that may be absorbed from the intestines or may be produced by the skin when the skin is exposed to sunlight (ultraviolet light of sunlight helps the body to form vitamin D). The absorbed vitamin D is converted into its active form to act as a hormone to regulate calcium absorption from the intestine and to regulate levels of calcium and phosphate in the bones. If there is a deficiency of Vitamin D, the body is unable to properly regulate calcium and phosphate levels. When the blood levels of these minerals become too low, it results in destruction of the support matrix of the bones.

In rickets, another mechanism in the body works to increase the blood calcium level. The parathyroid gland (four numbers of hormone producing glands, usually located in the neck) may increase its functioning rate to compensate for decreased levels of calcium in the bloodstream.To increase the level of calcium in the blood the hormone destroys the calcium present in the bones of the body and this results in further loss of calcium and phosphorous from the bones. In severe cases, cysts may develop in the bones. Vitamin D deficiency could be caused due to numerous reasons.

Environmental conditions where sunlight exposure is limited like indoor confinement or working indoors during daylight hours may reduce source of vitamin D.

A lack of vitamin D in the diet.

Problem of malabsorption called steatorrhea, in which the body is unable to absorb fats, and they are passed directly out the body in the stool. The result of this problem is that Vitamin D, which is usually absorbed with fat, and calcium are poorly absorbed. This poor absorption can be a result of digestive disorders. Steatorrhea could also lead to other deficiencies.

Due to tubular acidosis in which there is an increased amount of acid in the body fluids as a result of congenital or acquired kidney disorders.

A dietary lack of calcium and phosphorous may also play a part in nutritional causes of rickets.

A dietary lack of vitamin D may occasionally occur in people on a vegetarian diet who do not drink milk products or in people who are lactose intolerant (have trouble digesting milk products).

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Hey everyone! I am 19 years old and I was born with Rickets. I couldn't walk but I could only crawl backwards. so my mom took me to several hospitals to figure out was wrong with her baby girl. no doctor could ever find out what was wrong with me. Then someone told my mom about the Shriners Hospital which has a bone center in Shreveport Louisiana. They are the best hospital I have ever been to! I have had a mickey-G-tube in my stomach for vitamins, tubes up my nose, I used to have to take shots every day to help me grow, and also 5 surgeries on my legs to help straight my bowed legs out. They would always bow again and come out negative but when I was in the seventh grade I had my last final surgery to straight my legs and ever since then I am doing great! Shriners Hospital is an amazing hospital and I would advise any young child to go there for help they inspired me and made me want to go to college to become a nurse and work there one day to help kids in need just like they help me.
kasadiekay Tuesday, February 25, 2014
Please help me i am a poor man and i have rickets problem please help me.
Rickets Saturday, July 20, 2013
please may i know the differential diagnosis of rickets
shadmah Sunday, July 08, 2012
hiii im a 21 year old female I have Hypophosphatemic rickets I have never had any operations im trying to see how to go about doing so any tipss??
vanna21 Sunday, January 15, 2012
Do you have deformities?
cif12 Wednesday, May 09, 2012
I am 22 years old [girl] with hypophosphatemia, i had a surgery when i was 14 years old to close the growth plates in my knees to stop any more bowing in my legs. if you live close, at all, to California, UCSF is awesome. i am currently in a study for a new drug for treatment of this disease and so far, the drug has been helping me a lot. i still have a lot of bone pain and joint pains, but it does seem to be helping.
jennacismowski Thursday, September 13, 2012
Hey I am an 18 year old female and I am in the same situation. I have currently been getting more sharper pains my legs and find it really difficult to walk. Although I don't know whether to get the operation if it is just for cosmetic reasons.
nee_naw95 Thursday, October 24, 2013
i am 17 turning 18 this year, i had an operation last august on my left leg due to rickets and had metal plates placed in, this august i am having surgery again so that they can take the metal out, and then the same procedure is taking place on my right leg and then next summer theyre taking the metal plate out on right leg, they adjusted the alignment, i didnt realise alot of people have rickets until i saw this
Sana17 Sunday, June 05, 2011
i am 27,i have bowlegs i had my first surgery when i was 4,it reoccurred i dont really know what my kind is called but i think its generic cos my sis has it too.i am thinking of having another surgery,my fear is what if it reoccurs what chance have i got?
nuella Thursday, January 13, 2011
i am 22 and i have rickets [hypophosphatemia]. i had a surgery when i was 14 to close my growth plates (so that my legs didn't bow anymore), and when i was 19 i had a surgery to recorrect the bowing in my right leg. healing from the surgery was really, really hard (for me). i was on crutches for 8 months, and after i had totally healed, my right leg is basically the same shape as my left (that hasn't been operated on), though i do have a significant amount of less pain in my right leg (i think they moved bones around so it feels a lot less pressure, but it's a funky looking leg, if you ask me). i think it pretty much is inevitable that bowed legs will return to the same shape they are naturally, if you aren't on some kind of miracle medicine that will keep your bones strong enough to keep them in the shape that the operators placed them in.
jennacismowski Thursday, September 13, 2012
my sister son was suffering by vitamin-D resistant rickets.he is now 18 months old.is this rickets curable permanently?
basith Sunday, October 31, 2010
there are different types of rickets,I have Hypophosphatemic rickets (previously called vitamin D-resistant rickets) is a disorder in which the bones become painfully soft and bend easily because the blood contains low levels of phosphate.This very rare disorder is nearly always hereditary, passed as a dominant gene that is carried on the X chromosome, one of the two sex chromosomes. The genetic defect causes a kidney abnormality that allows an inappropriately high amount of phosphate to be excreted into the urine, resulting in low levels of phosphate in the blood. Because bones need phosphate for growth and strength, this deficiency causes defective bones. Females with hypophosphatemic rickets have less severe bone disease than males. In rare cases, the disorder develops as a result of certain cancers, such as giant cell tumors of bone, sarcomas, prostate cancer, and breast cancer. Hypophosphatemic rickets is not the same as rickets caused by vitamin D

deficiency (see Vitamins: Vitamin D Deficiency).

Jaxxxx Thursday, July 15, 2010
Hi there. My brother is 39-years-old and was born with hypophosphatemic rickets. He has walked with a cane for the past several years. He just had an operation in which a metal rod was inserted into his femur. Unfortunately, the rod went right through his bone and was unsuccessful. He is in excruciating pain and surviving on painkillers. I'd love to find resources for him of any kind. Any suggestions would be so very appreciated. Thank you.
guest Thursday, August 26, 2010
Hi I am a 37yr old woman that has been born with hypophosphatemic rickets, My mum is a carrier and so was my nan. I have been affected as a male would. and I have always been at the highest scale with severity. I underwent sergery as a teenager but I have bowed back as the years have gone by. My daughter has also been born with the condition and is undergiong full limb reconstruction. I have deteriated badly over the last 3yrs,and have constant pain.And the last 2 year My teath are falling out due to the amount of work that has been done on them over the years. Is any1 else having these problems?
bbshell Wednesday, March 30, 2011
Wow... How great to hear of others with the same condition. I am a 46 year old female and was born with rickets. I have had 9 operations on my knees. I was diagnosed with an underactive thyroid 2- 3 years ago and have been told today my cholestrol is too high, so now on tablets for that. I have been told the thyroid is quite common with a lack of vitamin D
Janey1901 Thursday, February 25, 2010
Hello, I'm a 31 year old female that suffers from rickets. I have had 6 surgeries on both legs. I had to have my left knee replaced and right hip as well. Now I also have decay of teeth (had to have many repairs), psoriasis, and am in lots of pain in my whole body.
msanna2122 Thursday, January 14, 2010
Hi, I'm a 30 year old female also suffering from rickets since the age of 2. I've also had a few operations, but have been doing well until recently. I'm really worried and afraid that i might also need a hip replacement. I just want to know how the hip replacement went. How long does it take to heal? I'm also walking on crutchers for the past two years. How do you get around?
guest Tuesday, February 16, 2010

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