The pH of the blood is normally maintained in a tight range between 7.35 to 7.45. Ions such as bicarbonate increase the pH and make the blood alkaline. On the other hand, hydrogen ions make it acidic.
The kidneys play a very important role in controlling the pH. The kidneys produce urine by filtering waste products from the blood. They consist of a large number of small units called nephrons. Each nephon consists of a cup shaped structure called the glomerulus and a long tubule. The tubules end in the collecting ducts. These ducts ultimately lead to the funnel shaped collection area called pelvis. Finally the urine flows into the bladder through a 25 cms small diameter pipe called the ureters that connect the pelvis of the kidneys to the bladder.
Filtration of blood takes place at the level of the glomerulus. The filtrate passes through the tubules that reabsorb a large amount and divert it back into the blood. The cells lining the first part of the tubules reabsorb bicarbonate from the urine. This process maintains the alkalinity of the blood and makes the urine more acidic. In the later or distal part, the tubules throw out hydrogen into the urine making it even more acidic. This process further reduces the acidity of the blood. A hormone aldosterone secreted by the adrenal glands also acts on the tubules at this level and plays a role in the excretion of hydrogen and potassium in exchange for sodium.
Any condition that affects the reabsorption of bicarbonate or secretion of acid or hydrogen ions into the urine or both at the kidney tubule level can cause RTA. In some cases, a permeability defect leading due to increased back leak of hydrogen ions can also contribute to the development of RTA.
There are 4 types of RTA,
► Type 1 or Classical Distal RTA,
► Type 2 or Proximal RTA,
► Type 3 which is a combination of Types 1 and 2,
► and Type 4 disease or Hyperkalemic RTA.
Type 3 disease is usually rare and often not included in the classification.
Complications of RTA include stunting of growth, bone problems (rickets in children and osteomalacia in adults), and kidney damage (kidney stones and kidney failure).
The condition is diagnosed by measuring the pH and electrolyte levels of blood and urine. Some other tests like sodium bicarbonate or ammonium chloride loading are also available for the diagnosis.
Renal Tubular Acidosis is treated using alkaline agents like sodium bicarbonate and sodium citrate or potassium citrate. In some cases, treating the cause helps the patient recover from RTA. Vitamin D may be needed in some cases. The condition should be diagnosed early and treatment instituted to prevent complications. Regular monitoring is also necessary in these patients.
Latest Publications and Research on Renal Tubular AcidosisPathological fractures as an initial presentation of Wilson's disease. - Published by PubMed
Primary presentation with acute flaccid quadriparesis in Sjogren's syndrome sans sicca. - Published by PubMed
Refractory rickets due to Fanconi's Syndrome secondary to Wilson's disease. - Published by PubMed
Identification of dominant negative effect of L522P mutation in the electrogenic Na(+)-HCO 3 (-) cotransporter NBCe1. - Published by PubMed
Acquired Proximal Renal Tubular Dysfunction in 9 Labrador Retrievers with Copper-Associated Hepatitis (2006-2012). - Published by PubMed