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Prostate Cancer / Cancer of Prostate

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Staging of Prostate Cancer

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If cancer is found in a prostate biopsy, it is graded in order to estimate how fast it is likely to grow and spread. Prostate cancers are graded according to how closely they look like normal prostate tissue.

Grading using Gleason system

The most commonly used prostate cancer grading system is called the Gleason system. This system assigns a Gleason grade ranging from 1 through 5 based on how much the arrangement of the cancer cells mimics the way normal prostate cells from glands. If the cancer cell clusters resemble the small, regular, evenly spaced glands of normal prostate tissue, a grade of 1 is assigned. If the cancer lacks these features and its cells seem to spread haphazardly through the prostate, it is a grade 5 tumor.

Cancers with a high Gleason score are more likely to have already spread beyond the prostate gland at the time they are detected. Therefore, the Gleason score along with the blood PSA level and DRE is useful in considering treatment options.

If the prostate biopsy finds a cancer, more tests are done to find out how far the cancer has spread. This is called staging. The stage of a cancer is the most important factor in choosing treatment options.

Physical examination
The physical exam, especially the digital rectal examination, is an important part of prostate cancer staging. The DRE can tell whether the cancer is limited to one side of the prostate, whether it has spread to the other side as well, or if it has spread beyond the prostate gland.

Imaging tests used for prostate cancer staging

Computed tomography
Commonly known as a CT or CAT scan, this test uses an x-ray beam to create a series of pictures of your body from any angles. A computer combines the information from all these pictures to produce a detailed cross-sectional image. This may reveal abnormally enlarged lymph nodes. Lymph nodes are a network of bean-sized collections of white blood cells that fight infection. Some prostate cancers spread to nearby lymph nodes, called pelvic lymph nodes. Enlarged pelvic lymph nodes could be a sign of spreading cancer, or could mean that your body is fighting an infection.

Magnetic resonance imaging (MRI)
MRI uses magnetic fields to create detailed cross-sectional pictures of selected areas of your body. These pictures can show abnormal areas of bones or lymph nodes that suggest cancer may have spread from the prostate.


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If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
Posted by:  prema  Posted on: 01/18/2010
Abiraterone in prostate cancer

The big news in oncology has been Johnson and Johnson purchasing Cougar Biotechnology for $1 billion. They have just bought promising prostate cancer compound, abiraterone.

So look out for this oral drug.

Dr.Shroff
The data hasn't even been announced at ASCO yet, that's this weekend coming, so one can only speculate that suitors got a sneak peek of the data under an NDA. A billion dollars certainly gets attention and raises the ante for future small oncology biotech deals.




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