Normal bladder control returns for
many patients within several weeks or months after radical
prostatectomy. Mild stress incontinence may persist
permanently after surgery in up to 35 per cent of men.
Impotence
Impotence, also known
as erectly dysfunction, is an inability to get an erection of
the penis. The nerves that allow men to get erections may be
damaged or removed by radical prostatectomy. Radiation therapy
and cryosurgery can also cause damage to these nerves.
However, during the first 3 to 12 months after radical
prostatectomy, most men will not be able to get a spontaneous
erection.
Side effects of cryosurgery
Freezing can damage nerves near the prostate and cause
impotence and incontinence. These complications occur about as
often after cryosurgery as they do after radical
prostatectomy. In addition, freezing may damage the bladder
and intestines, leading to pain, a burning sensation, and the
need to empty the bladder and bowels often. About 50 per cent
of men notice swelling of their penis and scrotum after
cryosurgery, usually lasting a couple of weeks.
Side effects of radiation therapy
These may include diarrhea with or without blood
in the stool, and an irritated large intestine. Occasionally,
normal bowel function does not return after treatment is
stopped. Both during and after treatment, other side effects
may include frequent urination, burning sensation while
urinating and blood in the urine. Radiation therapy may also
cause a feeling of fatigue that may not disappear until a
month or two after treatment stops. Impotence usually does not
occur right after radiation therapy but gradually develops
over one or more years.
Side effects of
chemotherapy
The side effects of chemotherapy
depend on the type of drugs, the amount taken, and the length
of treatment. Temporary side effects might include nausea and
vomiting, loss of appetite, loss of hair, and mouth sores.
Because chemotherapy can damage the blood-producing cells of
the bone marrow, patients may have low blood cell counts. This
can result in an increased change of infection. Most side
effects, however, disappear once treatment is stopped.
Side effects of hormone
therapy
1. Hot flashes similar to those
experienced by women in menopause, sometimes controllable with
other drugs such as Menace.
2. Breast enlargement,
which may be prevented by treatment with radiation to the
breasts prior to the start of the hormone blockade treatments.
3. Impotence-varying degrees are experienced.
Generally, potency returns hormone therapy is discontinued.
Actually, loss of libido is experienced more often than
impotency.
4. Other possible side effects include, anemia, weight gain, loss of muscle mass, loss of body hair,
and diarrhea.
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The big news in oncology has been Johnson and Johnson purchasing Cougar Biotechnology for $1 billion. They have just bought promising prostate cancer compound, abiraterone.
So look out for this oral drug.
Dr.Shroff
The data hasn't even been announced at ASCO yet, that's this weekend coming, so one can only speculate that suitors got a sneak peek of the data under an NDA. A billion dollars certainly gets attention and raises the ante for future small oncology biotech deals.