Pagets disease of the breast

The exact cause of the disease is unknown but certain women are at a higher risk of breast cancer. They are

Age: women above 50 years of age are at a high risk of suffering from breast cancer, which can be a cause for predisposition to Paget's disease.

Family history: women with several close relatives with breast cancer at a young age are at a higher risk of developing breast cancer but it is not necessary for them to choose a radical surgery to remove their breast as a preventive measure. Because it is proved that some of them would not have got breast cancer even if the breast (or breasts) were not removed.

Hormone Replacement Therapy (HRT): Long-term use of HRT for more than 10 years increases the risk of breast cancer. A combined HRT (estrogen plus progestin) increases the risk of breast cancer more than taking Estrogen Replacement Therapy (ERT).

Obesity: Overweight was also found to be linked with the development of breast cancer among older women.

Genetic alterations: Changes in certain genes like BRCA1, BRCA2, and others increase the risk of breast cancer among women.

Late childbearing: Women who have their first child at the age of 30 or later have an increased risk of developing breast cancer

Alcohol: Some studies show that there is a slightly higher risk of breast cancer among women who drink alcohol.

Radiotherapy: Women whose breasts were exposed to radiation at a younger age especially for the treatment of Hodgkin's disease are at a higher risk of developing breast cancer.

Most women who develop breast cancer have none of the risk factors listed above, other than the risk that comes with growing older.