Sir James Paget in 1874 was the first person to explain about the Paget's disease of the breast. He described the disease to be a chronic eczematous rash affecting the skin of the nipple and areola. The disease is also seen in close association with the intraductal carcinoma of the underlying mammary gland. In 1881 Thin reported his histological findings of the Paget's disease. Paget's disease of the breast occurs mainly in the women but is rarely seen in males also (1%).
Paget's disease of the breast -
It is a rare type of breast
cancer. It is otherwise called as the mammary Paget's disease (MPD). It
occurs in 1-4% of all people suffering from breast
The underlying breast cancer can be either an infiltrating ductal
carcinoma (90%) or ductal carcinoma in situ (DCIS)(10%). In this disease
there is an extensive proliferation of the Paget's cells (malignant
proliferation of the epithelial cells present in the epidermis).
Cancerous cells from the breast tumor break off and form Paget's cells
that pass through the milk ducts and reach the nipples or the epithelial
cells of the nipple spontaneously become cancerous Paget's cell.
Paget's disease of the breast is not to be confused with the Pagets
disease of the bone.