The cause is unknown in most of the cases. Genetically determined collagen disorder is suggested as the cause in some of the cases.
Some of the conditions often associated with MVP are:
► Marfan syndrome
► Osteogenesis imperfecta
► Ehler-Danlos syndrome
► Thoracic skeletal deformities (includes straight back syndrome)
Rarely MVP arises following conditions like rheumatic fever and diseases of the heart such as ischemic heart disease and cardiomyopathy.