Microscopic Polyangiitis (MPA)

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Treatment

Microscopic Polyangiitis is treated using cyclophosphamide and a corticosteroid.

The following treatments are used for MPA:

► MPA is treated using a corticosteroid (a drug that suppresses inflammation and immunity) and cyclophosphamide (an anticancer drug that suppresses immunity). The patient could undergo complete cure or may experience relapses during treatment.

► Other drugs that may be useful are methotrexate, azathioprine, cyclosporine, intravenous immunoglobulin and monoclonal antibodies.

► Plasmapheresis (a procedure where antibodies are removed from the blood) may be useful in severe cases.

► Trimethoprim sulfamethoxazole, an antibiotic, may be used to prevent Pneumocystis carinii pneumonia in MPA patients.

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I would like to connect with others that have this disease. What treatments have you tried, what has helped, what type of specialist do you see, etc. I have had this disease for a very long time but it has only been recently that a biopsy of my kidney was done and this disease diagnosed. I currently see a nephrologist, am on cellcept...had 4 infusions of rituxan. What symptoms do you have? Rosemary85

Concernedwife

My husband was diagnosed [after several hospitalizations with undiagnosed symptoms..high potassium, etc.] in May 2011. His kidneys have not responded to treatments. He is on dialysis. No doctors in our area are skilled in treatment. He developed infections requiring hospitalization when trying cytoxin. He is trying to be approved for rituxan. Did it help? He is fatigued, and he is in pain in his back and legs.

The rituxan I had in August is helping in reducing some of the inflammation....you can see improvement over the course of a year after the treatment. I take cellcept, did the 4 treatments [infusions] of rituxan and on prednisone. I live in N. Idaho...where are you from?

my husband has this disease, he has been on cytoxin, white blood cell count bottomed out twice. We are trying to get approved for rituxan, could you tell me about your experience with rituxan? Thank you sandy

A very informative article! Autoimmune diseases such as this significantly affects one's life. I hope that diseases such as this one will have a cure in the near future so that suffering will be alleviated.

WhiteDove600

I was diagnosed with MPA in 2007. I was given cyclosphomide, prednisone and other toxic medicine that threw the illness into remission. Eventually the toxic drugs were replaced with milder ones and in the Spring of 2010 I was gradually taken off the drugs. I take raprinil, not so much for blood pressure control, but more to protect my kidneys that took a hit back in 2007 before I was diagnosed. Prior to the attack I had survived two battles with breast cancer, but the pain of MPA made the cancer seem like a walk in the park. They say that I am still in remission, and for a while I forgot and worked in the garden breaking concrete, planting trees, moving furniture around and this after working full-time 5 days a week. Then recently, I noticed the rash on my ankles, inflamed sinuses, fatigue going up the stairs, dropping things, losing my balance. It happens when I get tired and then I remember, MPA is still in the background.

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