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Microscopic Polyangiitis (MPA)

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Diagnosis

A raised level of ANCA, CT scan and biopsy of the affected organs help to diagnose microscopic polyangiitis.

The following tests are used to diagnose MPA:

Blood tests: Blood tests show a raised ESR and increase in number of white blood cells. The level of an antibody called ANCA especially the MPOANCA type is raised. Rheumatoid factor may be high in some patients. Patients with kidney disease may show an increase in blood urea nitrogen and creatinine levels in the blood.

Urine Examination: Urine may show protein, blood and sediments in MPA patients with kidney disease.

Chest x-ray: Chest x-ray may indicate if the lungs are affected.

CT scan, mesentric angiography, endoscopy: These tests may be useful if the digestive tract is affected.

ECG: ECG is useful if the heart is affected.

EMG: EMG is useful to diagnose nerve involvement.

Biopsy: Biopsy of the affected tissues helps in the diagnosis of MPA.

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I would like to connect with others that have this disease. What treatments have you tried, what has helped, what type of specialist do you see, etc. I have had this disease for a very long time but it has only been recently that a biopsy of my kidney was done and this disease diagnosed. I currently see a nephrologist, am on cellcept...had 4 infusions of rituxan. What symptoms do you have? Rosemary85
rosemary85 Friday, October 28, 2011
My husband was diagnosed [after several hospitalizations with undiagnosed symptoms..high potassium, etc.] in May 2011. His kidneys have not responded to treatments. He is on dialysis. No doctors in our area are skilled in treatment. He developed infections requiring hospitalization when trying cytoxin. He is trying to be approved for rituxan. Did it help? He is fatigued, and he is in pain in his back and legs.
Concernedwife Monday, November 14, 2011
The rituxan I had in August is helping in reducing some of the inflammation....you can see improvement over the course of a year after the treatment. I take cellcept, did the 4 treatments [infusions] of rituxan and on prednisone. I live in N. Idaho...where are you from?
rosemary85 Sunday, December 18, 2011
my husband has this disease, he has been on cytoxin, white blood cell count bottomed out twice. We are trying to get approved for rituxan, could you tell me about your experience with rituxan? Thank you sandy
warrior128 Friday, September 20, 2013
A very informative article! Autoimmune diseases such as this significantly affects one's life. I hope that diseases such as this one will have a cure in the near future so that suffering will be alleviated.
ennairam_23 Thursday, February 03, 2011
I was diagnosed with MPA in 2007. I was given cyclosphomide, prednisone and other toxic medicine that threw the illness into remission. Eventually the toxic drugs were replaced with milder ones and in the Spring of 2010 I was gradually taken off the drugs. I take raprinil, not so much for blood pressure control, but more to protect my kidneys that took a hit back in 2007 before I was diagnosed. Prior to the attack I had survived two battles with breast cancer, but the pain of MPA made the cancer seem like a walk in the park. They say that I am still in remission, and for a while I forgot and worked in the garden breaking concrete, planting trees, moving furniture around and this after working full-time 5 days a week. Then recently, I noticed the rash on my ankles, inflamed sinuses, fatigue going up the stairs, dropping things, losing my balance. It happens when I get tired and then I remember, MPA is still in the background.
WhiteDove600 Wednesday, June 13, 2012

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