Cancer 2013 Apr 12
Tubulin-ß-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones.
Roque DM, Bellone S, English DP, Buza N, Cocco E, Gasparrini S, Bortolomai I, Ratner E, Silasi DA, Azodi M, Rutherford TJ, Schwartz PE, Santin AD
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
BACKGROUND: Uterine serous carcinoma (USC) is a subtype of endometrial cancer associated with chemoresistance and poor outcome. Overexpression of tubu...
Endocrinology 2013 Apr 11
The AF-1 activation function of estrogen receptor alpha is necessary and sufficient for uterine epithelial cell proliferation in vivo.
Abot A, Fontaine C, Raymond-Letron I, Flouriot G, Adlanmerini M, Buscato M, Otto C, Bergès H, Laurell H, Gourdy P, Lenfant F, Arnal JF
*INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, UPS, BP 84225, 31 432 Toulouse cedex 04, France;
Estrogen receptor-a (ERa) regulates gene transcription through the two activation functions (AF) AF-1 and AF-2. The crucial role of ERaAF-2 was previo...
Genes Chromosomes Cancer 2013 Apr 12
Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation.
Panagopoulos I, Thorsen J, Gorunova L, Haugom L, Bjerkehagen B, Davidson B, Heim S, Micci F
Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Endometrial stromal sarcomas (ESS) are genetically heterogeneous uterine tumors in which a JAZF1-SUZ12 chimeric gene resulting from the chromosomal tr...
Arch. Gynecol. Obstet. 2013 Apr 12
Uterine sarcoma-current management and experience from a regional cancer centre in North India.
Biswas A, Patel F, Kumar P, Srinivasan R, Bera A, Sharma SC, Rajwanshi A
Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, firstname.lastname@example.org.
PURPOSE: We intended to assess the clinicopathological features and treatment outcome in patients of uterine sarcoma. METHOD: A retrospective review o...
Int. J. Biochem. Cell Biol. 2013 Apr 8
BLU enhances the effects of anti-angiogenic activity in combination with gemcitabine-based chemotherapeutic agents.
Yoo HJ, Kim BR, Byun HJ, Park SY, Rho SB
Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
BLU is a tumor suppressor protein that is down-regulated in ovarian and cervical cancers. Its cellular biological functions appear related to cancer i...
Gynecol. Oncol. 2013 Apr 8
Trefoil Factor Family 3 (TFF3) Expression and Its Interaction With Estrogen Receptor (ER) in Endometrial Adenocarcinoma.
Mhawech-Fauceglia P, Wang D, Samrao D, Liu S, Dupont NC, Pejovic T
Department of Pathology at University of Southern California, Los Angeles-CA. Electronic address: email@example.com.
OBJECTIVES: TFF3 has been found to be up-regulated at the gene and protein levels in endometrioid adenocarcinoma (EAC) when compared to uterine serous...
Genetic Diversity in Normal Cell Populations is the Earliest Stage of Oncogenesis Leading to Intra-Tumor Heterogeneity.
Howk CL, Voller Z, Beck BB, Dai D
Department of Obstetrics and Gynecology, University of Iowa Iowa City, IA, USA.
Random mutations and epigenetic alterations provide a rich substrate for microevolutionary phenomena to occur in proliferating epithelial tissues. Gen...
Case Rep Oncol Med
Isolated uterine metastasis of invasive ductal carcinoma.
Arslan D, Tural D, Tatli AM, Akar E, Uysal M, Erdogan G
Department of Internal Medicine, Division of Medical Oncology, Medical Faculty, Akdeniz University, Antalya, Turkey.
Introduction. Most common metastasis sites of breast cancer are the lungs, bones, liver, and brain, whereas uterine involvement by metastatic breast d...
Int. J. Gynecol. Cancer 2013 Apr 8
The Use of Laparostomy in Patients With Gynecologic Cancer: First Report From a UK Cancer Center.
Kaushik S, Akhter K, Rufford B, Ind TE, Kolomainen DF, Butler J, Barton DP
*Division of Gynaecological Oncology, Royal Marsden Hospital, London, UK; †Cheltenham General Hospital, Cheltenham, Gloucestershire, UK; ‡Hampton Wick Surgery, Tudor House, Hampton, Wick, UK; and §Ipswich Hospital NHS Trust, Ipswich Hospital, Ipswich, UK.
OBJECTIVE: To report on the use of laparostomy after major gynecologic cancer surgery. METHODS: Operative records and surgical databases of patients w...
Cad Saude Publica
Survival analysis of women with cervical cancer treated at a referral hospital for oncology in Espírito Santo State, Brazil, 2000-2005.
Mascarello KC, Zandonade E, Amorim MH
Centro Universitário Norte do Espírito Santo, Universidade Federal do Espírito Santo, Vitória, Brasil.
Uterine cervical cancer is a leading cause of death from cancer in the female population worldwide. The aim of this study was to analyze survival of w...