Bioorg. Chem.
Synthesis, in vitro, and in vivo (Zebra fish) antitubercular activity of 7,8-dihydroquinolin-5(6H)-ylidenehydrazinecarbothioamides.
Marvadi SK, Krishna VS, Surineni G, Srilakshmi Reshma R, Sridhar B, Sriram D, Kantevari S
We, herein, describe the synthesis of a series of novel aryl tethered 7,8-dihydroquinolin-5(6H)-ylidenehydrazinecarbothioamides 4a-v, which showed in ...
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Source: PubMed
J Thorac Oncol 2020 Jan 30
Safety, Clinical Activity and Pharmacokinetics of Alflutinib (AST2818) in Advanced NSCLC Patients with EGFR T790M Mutation.
Shi Y, Zhang S, Hu X, Feng J, Ma Z, Zhou J, Yang N, Wu L, Liao W, Zhong D, Han X, Wang Z, Zhang X, Qin S, Ying K, Feng J, Fang J, Liu L, Jiang Y
Alflutinib (AST2818) is a newly developed third-generation EGFR tyrosine kinase inhibitor (TKI) selective for EGFR sensitizing and T790M resistant mut ...
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Source: PubMed
Immunobiology 2020 Jan 22
Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis.
Sokolowska A, Swierzko AS, Szala-Pozdziej A, Augustynowicz-Kopec E, Kozinska M, Niemiec T, Blachnio M, Borkowska-Tatar D, Jensenius JC, Thiel S, Dziadek J, Cedzynski M
We conducted a prospective study of 453 Polish patients suffering from pulmonary tuberculosis and 267 healthy controls. Selected polymorphisms of the ...
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Source: PubMed
Biochem. Biophys. Res. Commun. 2020 Jan 29
ppGpp ribosome dimerization model for bacterial persister formation and resuscitation.
Song S, Wood TK
Stress is ubiquitous for bacteria and can convert a subpopulation of cells into a dormant state known as persistence, in which cells are tolerant to a ...
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Source: PubMed
Lancet 2020 Jan 30
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L
In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemi ...
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Source: PubMed
