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Scleroderma
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Scleroderma - CREST syndrome - Signs - Symptoms - Diagnosis - Treatment - Prognosis
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Discov Med Capillaroscopic findings in systemic sclerosis -- Are they associated with disease duration and presence of digital ulcers? Lambova S, Müller-Ladner U (1) Clinic of Rheumatology, Department for Propaedeutics of Internal Medicine, Medical University, Plovdiv, Bulgaria. (2) Department for Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Giessen, Germany and Department for Rheumatology and Clinical Immunology, Kerckhoff Clinic, Bad Nauheim, Germany. Purpose of the Study: The aim of the study was to evaluate capillaroscopic pattern in systemic sclerosis (SSc) patients and its association with disea... Read More Source: PubMed 2011 Dec 2 Increased Accumulation of Extracellular Thrombospondin-2 Due to Low Degradation Activity Stimulates Type I Collagen Expression in Scleroderma Fibroblasts. Kajihara I, Jinnin M, Yamane K, Makino T, Honda N, Igata T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. The aim of the present study was to determine the expression and role of thrombospondin-2 (TSP-2) in systemic sclerosis (SSc). Both TSP-2 mRNA levels ... Read More Source: PubMed 2011 Dec 2 The p65 subunit of NF-?b inhibits col1a1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on the promoter by protein interaction with transcriptional activators (c-Krox, Sp1 and Sp3). Beauchef G, Bigot N, Kypriotou M, Renard E, Poree B, Widom R, Dompmartin-Blanchere A, Oddos T, Maquart F, Demoor M, Boumediene K, Galera P Caen University, France; Transcriptional mechanisms regulating type I collagen genes expression in physiopathological situations are not completely known. In this study, we ha... Read More Source: PubMed Pulm Med The PPAR? Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects. Bogatkevich GS, Highland KB, Akter T, Silver RM Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425-6370, USA. We present novel data demonstrating that the expression of PPAR? is reduced in lung fibroblasts from black SSc-ILD patients as compared to white patie... Read More Source: PubMed Cleve Clin J Med A less common source of dyspnea in scleroderma. Altahawi F, Alraies MC FACP, Department of Hospital Medicine, A13, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; alraiec@ccf.org. ... Read More Source: PubMed 2011 Dec 1 Endoglin in liver fibrosis. Finnson KW, Philip A Division of Plastic Surgery, Department of Surgery, Montreal General Hospital, McGill University, 1650 Cedar Avenue, Room C9-157, Montreal, QC, H3G 1A4, Canada. Liver fibrosis occurs in most types of chronic liver diseases and is characterized by excessive accumulation of extracellular matrix proteins, leading... Read More Source: PubMed 2011 Dec 2 Scleroderma Mimics. Nashel J, Steen V BIDMC, Division of Rheumatology and Lupus Center, Harvard University School of Medicine, 110 Francis Street, Suite 4B, Boston, MA, 02215, USA, jnashel@bidmc.harvard.edu. Scleroderma is a rare systemic autoimmune disease with multiple organ manifestations, including skin fibrosis. The groups of disorders classified as s... Read More Source: PubMed Eur Respir Rev Risk factors associated with pulmonary arterial hypertension in patients with systemic sclerosis and implications for screening. Denton CP, Hachulla E Royal Free Campus, UCL Medical School, London, UK. # Claude Huriez Hospital, Dept of Internal Medicine, National Scleroderma Centre, Lille University, Lille, France. Pulmonary arterial hypertension (PAH) is a relatively common complication of systemic sclerosis (SSc) affecting 5-12% of patients, and its development... Read More Source: PubMed 2011 Nov 29 Timing of transition between capillaroscopic patterns in systemic sclerosis. Sulli A, Pizzorni C, Smith V, Zampogna G, Ravera F, Cutolo M Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, n° 6 - 16132 Genova - Italy. OBJECTIVE.: Performing a medium-term longitudinal study to investigate the timing of transition through different patterns of nailfold microvascular d... Read More Source: PubMed Discov Med Capillaroscopic findings in systemic sclerosis -- Are they associated with disease duration and presence of digital ulcers? Lambova S, Müller-Ladner U (1) Clinic of Rheumatology, Department for Propaedeutics of Internal Medicine, Medical University, Plovdiv, Bulgaria. (2) Department for Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Giessen, Germany and Department for Rheumatology and Clinical Immunology, Kerckhoff Clinic, Bad Nauheim, Germany. Purpose of the Study: The aim of the study was to evaluate capillaroscopic pattern in systemic sclerosis (SSc) patients and its association with disea... Read More Source: PubMed Nan Fang Yi Ke Da Xue Xue Bao [Autoimmune polyendocrinopathy syndrome type 2 with Guillain-Barre syndrome and scleroderma: a case report]. Jia J, Yu JY, Wang X, Luo M First Clinical Medical College, Nanjing University of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.E-mail: njiajia2012@163.com. Autoimmune polyendocrinopathy syndrome is a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine ... Read More Source: PubMed Nan Fang Yi Ke Da Xue Xue Bao [Autoimmune polyendocrinopathy syndrome type 2 with Guillain-Barre syndrome and scleroderma: a case report]. Jia J, Yu JY, Wang X, Luo M First Clinical Medical College, Nanjing University of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.E-mail: njiajia2012@163.com. Autoimmune polyendocrinopathy syndrome is a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine ... Read More Source: PubMed 2011 Dec 2 Increased Accumulation of Extracellular Thrombospondin-2 Due to Low Degradation Activity Stimulates Type I Collagen Expression in Scleroderma Fibroblasts. Kajihara I, Jinnin M, Yamane K, Makino T, Honda N, Igata T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. The aim of the present study was to determine the expression and role of thrombospondin-2 (TSP-2) in systemic sclerosis (SSc). Both TSP-2 mRNA levels ... Read More Source: PubMed 2011 Dec 2 The p65 subunit of NF-?b inhibits col1a1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on the promoter by protein interaction with transcriptional activators (c-Krox, Sp1 and Sp3). Beauchef G, Bigot N, Kypriotou M, Renard E, Poree B, Widom R, Dompmartin-Blanchere A, Oddos T, Maquart F, Demoor M, Boumediene K, Galera P Caen University, France; Transcriptional mechanisms regulating type I collagen genes expression in physiopathological situations are not completely known. In this study, we ha... Read More Source: PubMed Pulm Med The PPAR? Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects. Bogatkevich GS, Highland KB, Akter T, Silver RM Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425-6370, USA. We present novel data demonstrating that the expression of PPAR? is reduced in lung fibroblasts from black SSc-ILD patients as compared to white patie... Read More Source: PubMed Cleve Clin J Med A less common source of dyspnea in scleroderma. Altahawi F, Alraies MC FACP, Department of Hospital Medicine, A13, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; alraiec@ccf.org. ... Read More Source: PubMed 2011 Dec 1 Endoglin in liver fibrosis. Finnson KW, Philip A Division of Plastic Surgery, Department of Surgery, Montreal General Hospital, McGill University, 1650 Cedar Avenue, Room C9-157, Montreal, QC, H3G 1A4, Canada. Liver fibrosis occurs in most types of chronic liver diseases and is characterized by excessive accumulation of extracellular matrix proteins, leading... Read More Source: PubMed 2011 Dec 2 Scleroderma Mimics. Nashel J, Steen V BIDMC, Division of Rheumatology and Lupus Center, Harvard University School of Medicine, 110 Francis Street, Suite 4B, Boston, MA, 02215, USA, jnashel@bidmc.harvard.edu. Scleroderma is a rare systemic autoimmune disease with multiple organ manifestations, including skin fibrosis. The groups of disorders classified as s... Read More Source: PubMed Eur Respir Rev Risk factors associated with pulmonary arterial hypertension in patients with systemic sclerosis and implications for screening. Denton CP, Hachulla E Royal Free Campus, UCL Medical School, London, UK. # Claude Huriez Hospital, Dept of Internal Medicine, National Scleroderma Centre, Lille University, Lille, France. Pulmonary arterial hypertension (PAH) is a relatively common complication of systemic sclerosis (SSc) affecting 5-12% of patients, and its development... Read More Source: PubMed 2011 Nov 29 Timing of transition between capillaroscopic patterns in systemic sclerosis. Sulli A, Pizzorni C, Smith V, Zampogna G, Ravera F, Cutolo M Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, n° 6 - 16132 Genova - Italy. OBJECTIVE.: Performing a medium-term longitudinal study to investigate the timing of transition through different patterns of nailfold microvascular d... Read More Source: PubMed |
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