Reduced crowding and poor contour detection in schizophrenia are consistent with weak surround inhibition.
Robol V, Tibber MS, Anderson EJ, Bobin T, Carlin P, Shergill SS, Dakin SC
Department of General Psychology, University of Padua, Padua, Italy.
Detection of visual contours (strings of small oriented elements) is markedly poor in schizophrenia. This has previously been attributed to an inabili...
Memantine reverses social withdrawal induced by ketamine in rats.
Uribe E, Landaeta J, Wix R, Eblen A
Laboratorio de Neurofisiología, Escuela De Ciencias Biomédicas y Tecnológicas Dr. Guillermo Mujica Sevilla, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. ; Hospital Dr. Rafael González Plaza, Departamento de Neuropsiquiatría. INSALUD, Gobernación del Estado Carabobo. Edo. Carabobo 2001, Venezuela.
The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in r...
Neuropharmacology 2013 Apr 11
NMDA receptors in nervous system diseases.
Zhou Q, Sheng M
Department of Neuroscience, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: email@example.com.
NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic ne...
Prog. Neuropsychopharmacol. Biol. Psychiatry 2013 Apr 11
Association of serotonin transporter gene (SLC6A4) polymorphisms with schizophrenia susceptibility and symptoms in a Chinese-Han population.
Li W, Yang Y, Lin J, Wang S, Zhao J, Yang G, Wang X, Ding M, Zhang H, Lv L
Department of Psychiatry, Henan Mental Hospital ,The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China; Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, China. Electronic address: firstname.lastname@example.org.
Schizophrenia (SZ) is a complex psychiatric disorder with a strong genetic component. The serotonin transporter (SERT), encoded by solute carrier fami...
Med. Hypotheses 2013 Apr 11
The ventral portion of the CA1 region of the hippocampus and the prefrontal cortex as candidate regions for neuromodulation in schizophrenia.
Ewing SG, Winter C
Bereich Experimentelle Psychiatrie, Universitätsklinik Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. Electronic address: email@example.com.
Existing antipsychotic drugs are most effective in the treatment of the positive symptoms of schizophrenia. However, they are associated with consider...
Schizophr. Res. 2013 Apr 9
Specific vs general cognitive remediation for executive functioning in schizophrenia: A multicenter randomized trial.
Franck N, Duboc C, Sundby C, Amado I, Wykes T, Demily C, Launay C, Le Roy V, Bloch P, Willard D, Todd A, Petitjean F, Foullu S, Briant P, Grillon ML, Deppen P, Verdoux H, Bralet MC, Januel D, Riche B, Roy P, Vianin P
Service Universitaire de Réhabilitation, CH Le Vinatier, Bron, France; Cognitive Neuroscience Centre, UMR 5229 CNRS & Claude Bernard University, Université de Lyon, Bron, France. Electronic address: firstname.lastname@example.org.
BACKGROUND: This study assesses the benefits of an individualized therapy (RECOS program) compared with the more general cognitive remediation therapy...
Schizophr. Res. 2013 Apr 9
Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3ß signaling pathway.
Peng L, Zhu D, Feng X, Dong H, Yue Q, Zhang J, Gao Q, Hao J, Zhang X, Liu Z, Sun J
Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China.
Recent studies have suggested that neurodegeneration is involved in the pathogenesis of schizophrenia, and some atypical antipsychotics appear to prev...
Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver.
Schobel SA, Chaudhury NH, Khan UA, Paniagua B, Styner MA, Asllani I, Inbar BP, Corcoran CM, Lieberman JA, Moore H, Small SA
Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA; The New York State Psychiatric Institute, New York, NY 10032, USA.
The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced size. It remains unknown whether these abnormalities are mechani...
A mechanistic approach to preventing schizophrenia in at-risk individuals.
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: email@example.com.
In this issue of Neuron, Schobel et al. (2013) report that excess hippocampal glutamate may cause transition to psychosis in individuals at high risk ...