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Rickets / Paediatric Osteomalacia

Latest Publication and Research on Rickets

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  2011 Nov 30  

Early Animal Models of Rickets and Proof of a Nutritional Deficiency Hypothesis.

Chesney RW

ABSTRACT: In the period between 1880 and 1930 the role of nutrition and of a nutritional deficiency as a cause of rickets was established based upon t... Read More

Source: PubMed

  2011 Dec 2  

The Decade of Ideas Leading to a Cure for Rickets.

Chesney RW

Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Children's Foundation Research Center, Memphis, TN.

... Read More

Source: PubMed

  2011 Nov 29  

Should 25-Hydroxyvitamin D and Bone Density Using DXA be Tested in Adolescents With Lumbar Stress Fractures of the Pars Interarticularis?

McClellan JW, Vernon BA, White MA, Stamm S, Ryschon KL

University of Nebraska Medical Center, Omaha, NE.

STUDY DESIGN:: Retrospective study. OBJECTIVE:: To determine if 25-hydroxyvitamin D (25[OH]D) level measurement and bone mineral density (BMD) using d... Read More

Source: PubMed

Cas. Lek. Cesk.    

[Hypophosphatasia--biochemical and clinical manifestations, molecular genetic principles].

Chandoga I, Futas J, Petrovic R, Chandoga J

II. ortopedicko-traumatologická klinika LF UK a UN, Bratislava, Slovenská republika. chandoga@gmail.com

Hypophosphatasia is a rare hereditary metabolic disorder accompanying deficit of tissue nonspecific serum alkaline phosphatase. The incidence of overt... Read More

Source: PubMed

Ann. Nutr. Metab.    

Vitamin d recommendations - beyond deficiency.

Biesalski HK

Department of Biological Chemistry and Nutrition, Food Security Center, University of Hohenheim, Stuttgart, Germany.

Vitamin D plays an important role in regular bone growth and in adequate function of the innate immune system, including barrier functions of mucous m... Read More

Source: PubMed

  2011 Nov 25  

Vitamin D and respiratory infection in adults.

Laaksi I

Department of Cell Biology and Anatomy, Medical School, University of Tampere, Medisiinarinkatu 3, 33014 Tampere, Finland.

Vitamin D insufficiency is a global issue that has significant implications for health. The classical role of vitamin D in bone mineralisation is well... Read More

Source: PubMed

Ir Med J    

Maternal and infant nutritional supplementation practices in Ireland: implications for clinicians and policymakers.

Tarrant RC, Sheridan-Pereira M, McCarthy RA, Younger KM, Kearney JM

Our Lady's Children's Hospital, Crumlin, Dublin 12.

This prospective Irish observational study examined maternal and infant nutritional supplement use. From an initial sample of 539 mothers recruited fr... Read More

Source: PubMed

  2011 Nov 15  

Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection.

White JH

Department of Physiology, McIntyre Bldg., Rm. 1112, 3655 Drummond St., Montreal, Qc, Canada H3G 1Y6.

Vitamin D was discovered as the cure for nutritional rickets. Classically, hormonal 1,25-dihydroxyvitamin D (1,25D), produced in the kidney by CYP27B1... Read More

Source: PubMed

  2011 Nov 20  

Growth in PHEX-associated X-linked hypophosphatemic rickets: the importance of early treatment.

Quinlan C, Guegan K, Offiah A, Neill RO, Hiorns MP, Ellard S, Bockenhauer D, Hoff WV, Waters AM

Department of Nephro-Urology, Great Ormond Street Hospital, London, UK.

Inactivating mutations in phosphate-regulating endopeptidase (PHEX) cause X-linked hypophosphatemic rickets (XLHR) characterized by phosphaturia, hypo... Read More

Source: PubMed

  2011 Nov 9  

Evaluation of Hypophosphatemia: Lessons From Patients With Genetic Disorders.

Bacchetta J, Salusky IB

David Geffen School of Medicine, Division of Pediatric Nephrology, University of California Los Angeles, Los Angeles, CA.

Phosphate is a key component of several physiologic pathways, such as skeletal development, bone mineralization, membrane composition, nucleotide stru... Read More

Source: PubMed

  2011 Dec 2  

The Decade of Ideas Leading to a Cure for Rickets.

Chesney RW

Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Children's Foundation Research Center, Memphis, TN.

... Read More

Source: PubMed

  2011 Nov 29  

Should 25-Hydroxyvitamin D and Bone Density Using DXA be Tested in Adolescents With Lumbar Stress Fractures of the Pars Interarticularis?

McClellan JW, Vernon BA, White MA, Stamm S, Ryschon KL

University of Nebraska Medical Center, Omaha, NE.

STUDY DESIGN:: Retrospective study. OBJECTIVE:: To determine if 25-hydroxyvitamin D (25[OH]D) level measurement and bone mineral density (BMD) using d... Read More

Source: PubMed

Cas. Lek. Cesk.    

[Hypophosphatasia--biochemical and clinical manifestations, molecular genetic principles].

Chandoga I, Futas J, Petrovic R, Chandoga J

II. ortopedicko-traumatologická klinika LF UK a UN, Bratislava, Slovenská republika. chandoga@gmail.com

Hypophosphatasia is a rare hereditary metabolic disorder accompanying deficit of tissue nonspecific serum alkaline phosphatase. The incidence of overt... Read More

Source: PubMed

Ann. Nutr. Metab.    

Vitamin d recommendations - beyond deficiency.

Biesalski HK

Department of Biological Chemistry and Nutrition, Food Security Center, University of Hohenheim, Stuttgart, Germany.

Vitamin D plays an important role in regular bone growth and in adequate function of the innate immune system, including barrier functions of mucous m... Read More

Source: PubMed

  2011 Nov 25  

Vitamin D and respiratory infection in adults.

Laaksi I

Department of Cell Biology and Anatomy, Medical School, University of Tampere, Medisiinarinkatu 3, 33014 Tampere, Finland.

Vitamin D insufficiency is a global issue that has significant implications for health. The classical role of vitamin D in bone mineralisation is well... Read More

Source: PubMed

Ir Med J    

Maternal and infant nutritional supplementation practices in Ireland: implications for clinicians and policymakers.

Tarrant RC, Sheridan-Pereira M, McCarthy RA, Younger KM, Kearney JM

Our Lady's Children's Hospital, Crumlin, Dublin 12.

This prospective Irish observational study examined maternal and infant nutritional supplement use. From an initial sample of 539 mothers recruited fr... Read More

Source: PubMed

  2011 Nov 15  

Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection.

White JH

Department of Physiology, McIntyre Bldg., Rm. 1112, 3655 Drummond St., Montreal, Qc, Canada H3G 1Y6.

Vitamin D was discovered as the cure for nutritional rickets. Classically, hormonal 1,25-dihydroxyvitamin D (1,25D), produced in the kidney by CYP27B1... Read More

Source: PubMed

  2011 Nov 20  

Growth in PHEX-associated X-linked hypophosphatemic rickets: the importance of early treatment.

Quinlan C, Guegan K, Offiah A, Neill RO, Hiorns MP, Ellard S, Bockenhauer D, Hoff WV, Waters AM

Department of Nephro-Urology, Great Ormond Street Hospital, London, UK.

Inactivating mutations in phosphate-regulating endopeptidase (PHEX) cause X-linked hypophosphatemic rickets (XLHR) characterized by phosphaturia, hypo... Read More

Source: PubMed

  2011 Nov 9  

Evaluation of Hypophosphatemia: Lessons From Patients With Genetic Disorders.

Bacchetta J, Salusky IB

David Geffen School of Medicine, Division of Pediatric Nephrology, University of California Los Angeles, Los Angeles, CA.

Phosphate is a key component of several physiologic pathways, such as skeletal development, bone mineralization, membrane composition, nucleotide stru... Read More

Source: PubMed

  2011 Nov 30  

Early Animal Models of Rickets and Proof of a Nutritional Deficiency Hypothesis.

Chesney RW

ABSTRACT: In the period between 1880 and 1930 the role of nutrition and of a nutritional deficiency as a cause of rickets was established based upon t... Read More

Source: PubMed


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Posted by:  vanna21(Guest)  Posted on: 01/15/2012
hiii im a 21 year old female I have Hypophosphatemic rickets I have never had any operations im trying to see how to go about doing so any tipss??


Posted by:  cif12(Guest)  Posted on: 05/09/2012
Do you have deformities?




Posted by:  Sana17  Posted on: 06/05/2011
i am 17 turning 18 this year, i had an operation last august on my left leg due to rickets and had metal plates placed in, this august i am having surgery again so that they can take the metal out, and then the same procedure is taking place on my right leg and then next summer theyre taking the metal plate out on right leg, they adjusted the alignment, i didnt realise alot of people have rickets until i saw this



Posted by:  nuella  Posted on: 01/13/2011
i am 27,i have bowlegs i had my first surgery when i was 4,it reoccurred i dont really know what my kind is called but i think its generic cos my sis has it too.i am thinking of having another surgery,my fear is what if it reoccurs what chance have i got?



Posted by:  basith  Posted on: 10/31/2010
my sister son was suffering by vitamin-D resistant rickets.he is now 18 months old.is this rickets curable permanently?



Posted by:  Jaxxxx(Guest)  Posted on: 07/15/2010
there are different types of rickets,I have Hypophosphatemic rickets (previously called vitamin D-resistant rickets) is a disorder in which the bones become painfully soft and bend easily because the blood contains low levels of phosphate.This very rare disorder is nearly always hereditary, passed as a dominant gene that is carried on the X chromosome, one of the two sex chromosomes. The genetic defect causes a kidney abnormality that allows an inappropriately high amount of phosphate to be excreted into the urine, resulting in low levels of phosphate in the blood. Because bones need phosphate for growth and strength, this deficiency causes defective bones. Females with hypophosphatemic rickets have less severe bone disease than males. In rare cases, the disorder develops as a result of certain cancers, such as giant cell tumors of bone, sarcomas, prostate cancer, and breast cancer. Hypophosphatemic rickets is not the same as rickets caused by vitamin D

deficiency (see Vitamins: Vitamin D Deficiency).


Posted by:  guest  Posted on: 08/26/2010
Hi there. My brother is 39-years-old and was born with hypophosphatemic rickets. He has walked with a cane for the past several years. He just had an operation in which a metal rod was inserted into his femur. Unfortunately, the rod went right through his bone and was unsuccessful. He is in excruciating pain and surviving on painkillers. I'd love to find resources for him of any kind. Any suggestions would be so very appreciated. Thank you.



Posted by:  bbshell(Guest)  Posted on: 03/30/2011
Hi I am a 37yr old woman that has been born with hypophosphatemic rickets, My mum is a carrier and so was my nan. I have been affected as a male would. and I have always been at the highest scale with severity. I underwent sergery as a teenager but I have bowed back as the years have gone by. My daughter has also been born with the condition and is undergiong full limb reconstruction. I have deteriated badly over the last 3yrs,and have constant pain.And the last 2 year My teath are falling out due to the amount of work that has been done on them over the years. Is any1 else having these problems?




Posted by:  Janey1901(Guest)  Posted on: 02/25/2010
Wow... How great to hear of others with the same condition. I am a 46 year old female and was born with rickets. I have had 9 operations on my knees. I was diagnosed with an underactive thyroid 2- 3 years ago and have been told today my cholestrol is too high, so now on tablets for that. I have been told the thyroid is quite common with a lack of vitamin D



Posted by:  msanna2122(Guest)  Posted on: 01/14/2010
Hello, I'm a 31 year old female that suffers from rickets. I have had 6 surgeries on both legs. I had to have my left knee replaced and right hip as well. Now I also have decay of teeth (had to have many repairs), psoriasis, and am in lots of pain in my whole body.


Posted by:  guest  Posted on: 02/16/2010
Hi, I'm a 30 year old female also suffering from rickets since the age of 2. I've also had a few operations, but have been doing well until recently. I'm really worried and afraid that i might also need a hip replacement. I just want to know how the hip replacement went. How long does it take to heal? I'm also walking on crutchers for the past two years. How do you get around?




Posted by:  kaneasgirl  Posted on: 08/12/2009
I am a twenty five year old female with rickets. I have had one knee surgery to straighten it, but I have never really had any bone pains until now! I am taking osteobioflex and calcium, but I am still in a lot of pain. The pain is just in my shoulder right now, but it is keeping me from sleeping and doing my job!


Posted by:  simple_sweet  Posted on: 11/02/2010
can u plz tell me 4m where u had ur surgery. m 23 yrs old.i hv rickets since childhood.. searching 4 surgery to straighten me legs. please tell me is der any pain or problems in lleg bones after surgery and where u had operated. hw many operations have to be done?? and wat would be cost 4 it. i'll be really thankful to u..




Posted by:  radoo(Guest)  Posted on: 05/21/2009
hi i also have a 16month old daughter with rickets. the dr said that her body is resistant to the vit d tablet, hence she needs to be given a 'special' kind of vit d tablet to treat her condition. i am just wondering if the vit d dosage will have any side effect on her? jus a 2nd opinion from those who have been experiencing this. tq for ur response.



Posted by:  alicianbodway(Guest)  Posted on: 03/09/2009
I am 14 Years Old and Have Herretitary Rickets. My Legs Are Severly Bowed Because of it. COmment If Any Questions. I Have Had 3 Surgurys and my 4th is coming up.


Posted by:  guest  Posted on: 09/27/2009
How are you legs doing? Are they okay now?



Posted by:  guest  Posted on: 10/04/2009
Good Luck Girlie !!! I will be prayin' for ya :-]



Posted by:  alicianbodway(Guest)  Posted on: 10/06/2009
Yesss, they are doing great . i just got my external fixitor off my leg 2 weeks ago and i am so hapy about it. Thanks for the comments !



Posted by:  guest  Posted on: 11/02/2009
omg iwish you the best of luck



Posted by:  guest  Posted on: 03/16/2010
I have rickets also. I had external fixators on both legs for a year. Where are u from?



Posted by:  atul_qwerty(Guest)  Posted on: 10/01/2010
are ur legs perfectly ok now..???




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