Oncoimmunology

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6.

Czerwinska P, Rucinski M, Wlodarczyk N, Jaworska A, Grzadzielewska I, Gryska K, Galus L, Mackiewicz J, Mackiewicz A

We developed a therapeutic, gene-modified, allogeneic melanoma vaccine (AGI-101H), which, upon genetic modification, acquired melanoma stem cell-like ... Read More

Source: PubMed

Transgenic Res. 2020 Jan 29

Consideration of familiarity accumulated in the confined field trials for environmental risk assessment of genetically modified soybean (Glycine max) in Japan.

Matsushita A, Goto H, Takahashi Y, Tsuda M, Ohsawa R

To date, there have been 160 regulatory approvals for environmental safety in Japan for the major genetically modified (GM) crops, including corn, soy ... Read More

Source: PubMed

Mar. Biotechnol. 2020 Jan 29

Acetylome Analysis Reveals Population Differentiation of the Pacific Oyster Crassostrea gigas in Response to Heat Stress.

Li A, Li L, Wang W, Zhang G

Lysine acetylation of proteins is a highly conserved post-translational modification that plays an important regulatory role in almost every aspect of ... Read More

Source: PubMed

Food Sci Nutr

Pro-vitamin A carotenoids in East African highland banana and other Musa cultivars grown in Uganda.

Mbabazi R, Harding R, Khanna H, Namanya P, Arinaitwe G, Tushemereirwe W, Dale J, Paul JY

Bananas and plantains (Musa spp.) are an important staple and food security crop in sub-Saharan Africa. In Uganda, where the consumption of East Afric ... Read More

Source: PubMed

J. Agric. Food Chem. 2020 Jan 27

Engineering Saccharomyces cerevisiae coculture platform for the production of flavonoids.

Du Y, Yang B, Yi Z, Hu L, Li M

Flavonoids are valuable natural products widely used in human health and nutrition applications. Engineering microbial consortia to express complex fl ... Read More

Source: PubMed