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Endometrial Biopsy

Latest Publication and Research on Endometrial Biopsy

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  2011 Nov 24  

A Pilot Study of Microsatellite Instability and Endometrial Cancer Survival in White and African American Women.

Cote ML, Kam A, Chang C, Raskin L, Reding KW, Cho KR, Gruber SB, Ali-Fehmi R, Chang CY

Wayne State University School of Medicine (M.L.C., A.K., R.A-F.) Karmanos Cancer Institute (M.L.C.) Department of Epidemiology (C.C., K.W.R., S.B.G.), University of Michigan School of Public Health Department of Internal Medicine (L.R., S.B.G.) Pathology (K.R.C.) Human Genetics (S.B.G.), University of Michigan Medical School, MI Obstetrics/Gynecology Department (C.Y-Y.C.), China Medical University Hospital, Taichung, Taiwan.

Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United States and can be classified on the basis of various pathologic... Read More

Source: PubMed

  2011 Nov 24  

P16INK4a Expression in Undifferentiated Carcinoma of the Uterus Does Not Exclude Its Endometrial Origin.

Saad RS, Mashhour M, Noftech-Mozes S, Ismiil N, Dubé V, Ghorab Z, Faragalla H, Khalifa MA

Department of Pathology, Sunnybrook Health Sciences Center, University of Toronto, ON, Canada.

Undifferentiated carcinoma of the endometrium is a rare neoplasm, which, when involving the cervix, raises a question about its origin. Diffuse p16 po... Read More

Source: PubMed

  2011 Nov 24  

Pathologic Scoring of PTEN Immunohistochemistry in Endometrial Carcinoma is Highly Reproducible.

Garg K, Broaddus RR, Soslow RA, Urbauer DL, Levine DA, Djordjevic B

Department of Pathology (K.G., R.A.S.), Memorial Sloan Kettering Cancer Center Department of Pathology (R.R.B., B.D.) Department of Epidemiology and Biostatistics (D.L.U.), MD Anderson Cancer Center Department of Surgery (D.A.L.), Gynecologic Oncology, Memorial Sloan Kettering Cancer Center Department of Pathology and Laboratory Medicine (B.D.), The Ottawa Hospital, University of Ottawa.

Endometrial carcinomas show frequent PTEN-PI3K pathway abnormalities, and there are currently multiple trials focused on PI3K pathway inhibitors in pa... Read More

Source: PubMed

  2011 Dec 3  

Targeted detection of 65kDa heat shock protein gene in endometrial biopsies for reliable diagnosis of genital tuberculosis.

Prasad S, Singhal M, Negi SS, Gupta S, Singh S, Rawat DS, Rai A

IVF and Reproductive Biology Centre, Department of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, India.

OBJECTIVE: To evaluate the clinical utility of PCR compared with other available diagnostic modalities in prompt diagnosis of female genital tuberculo... Read More

Source: PubMed

  2011 Dec 1  

Update on the management of menometrorrhagia: new surgical approaches.

Fernandez H

Service Gynécologie Obstétrique, Hôpital Bicętre , Le Kremlin Bicętre , France.

Hysterectomy has traditionally been the definitive surgical approach for heavy menstrual bleeding. However, the more modern concept of 'save the uteru... Read More

Source: PubMed

Ceska Gynekol    

[Current classification of malignant tumours in gynecological oncology--part II].

Sehnal B, Driák D, Kmonícková E, Dvorská M, Hosová M, Citterbart K, Halaska M, Kolarík D

Gynekologicko-porodnická klinika, 1. LF UK a FN Na Bulovce, Praha.

Review of new staging systems for gynaecological cancers and their impact on prognosis and planning treatment.... Read More

Source: PubMed

Acta Dermatovenerol Alp Panonica Adriat    

Histopathology of cervical precursor lesions and cancer.

Lax S

Department of Pathology, Graz West General Hospital, Göstingerstrasse 22, A-8020 Graz, Austria. sigurd.lax@medunigraz.at, sigurd.lax@lkh-grazwest.at.

The most frequent types of cervical cancer are squamous-cell carcinoma and adenocarcinoma, which develop from the distinctive precursor lesions cervic... Read More

Source: PubMed

ScientificWorldJournal    

mRNA-Expression of ERa, ERß, and PR in Clonal Stem Cell Cultures Obtained from Human Endometrial Biopsies.

Schüring AN, Braun J, Wüllner S, Kiesel L, Götte M

Department of Gynecology and Obstetrics, University of Münster, Medical Center, 48149 Münster, Germany.

Background. Proliferation and differentiation of the endometrium are regulated by estrogen and progesterone. The enormous regenerative capacity of the... Read More

Source: PubMed

  2011 Nov 29  

Histopathology diagnosis in women who underwent a hysterectomy for a benign condition.

Saleh SS, Fram K

Department of Obstetrics and Gynaecology, Jordan University Hospital, PO Box 13046, Amman, 11942, Jordan, sssaleh@hotmail.com.

PURPOSE: To study the correlation between the preoperative clinical diagnosis and the final histopathology of hysterectomy speci... Read More

Source: PubMed

  2011 Nov 24  

Endometriosis-associated Serous Borderline Tumor and Endometrial Stromal Sarcoma of the Ovary: A Report of a Rare Lesion in an Infant.

Ho RS, Chan GC, Ha SY, Ip PP

Department of Pathology (R.S.L.H, P.P.C.I) Paediatrics and Adolescent Medicine (G.C.F.C, S.Y.H), The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR.

Endometriosis in infancy is most unusual, and associated tumors in this age group are exceptionally rare. We report a case of a serous borderline tumo... Read More

Source: PubMed

  2011 Nov 24  

A Pilot Study of Microsatellite Instability and Endometrial Cancer Survival in White and African American Women.

Cote ML, Kam A, Chang C, Raskin L, Reding KW, Cho KR, Gruber SB, Ali-Fehmi R, Chang CY

Wayne State University School of Medicine (M.L.C., A.K., R.A-F.) Karmanos Cancer Institute (M.L.C.) Department of Epidemiology (C.C., K.W.R., S.B.G.), University of Michigan School of Public Health Department of Internal Medicine (L.R., S.B.G.) Pathology (K.R.C.) Human Genetics (S.B.G.), University of Michigan Medical School, MI Obstetrics/Gynecology Department (C.Y-Y.C.), China Medical University Hospital, Taichung, Taiwan.

Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United States and can be classified on the basis of various pathologic... Read More

Source: PubMed

  2011 Nov 24  

P16INK4a Expression in Undifferentiated Carcinoma of the Uterus Does Not Exclude Its Endometrial Origin.

Saad RS, Mashhour M, Noftech-Mozes S, Ismiil N, Dubé V, Ghorab Z, Faragalla H, Khalifa MA

Department of Pathology, Sunnybrook Health Sciences Center, University of Toronto, ON, Canada.

Undifferentiated carcinoma of the endometrium is a rare neoplasm, which, when involving the cervix, raises a question about its origin. Diffuse p16 po... Read More

Source: PubMed

  2011 Nov 24  

Pathologic Scoring of PTEN Immunohistochemistry in Endometrial Carcinoma is Highly Reproducible.

Garg K, Broaddus RR, Soslow RA, Urbauer DL, Levine DA, Djordjevic B

Department of Pathology (K.G., R.A.S.), Memorial Sloan Kettering Cancer Center Department of Pathology (R.R.B., B.D.) Department of Epidemiology and Biostatistics (D.L.U.), MD Anderson Cancer Center Department of Surgery (D.A.L.), Gynecologic Oncology, Memorial Sloan Kettering Cancer Center Department of Pathology and Laboratory Medicine (B.D.), The Ottawa Hospital, University of Ottawa.

Endometrial carcinomas show frequent PTEN-PI3K pathway abnormalities, and there are currently multiple trials focused on PI3K pathway inhibitors in pa... Read More

Source: PubMed

  2011 Dec 3  

Targeted detection of 65kDa heat shock protein gene in endometrial biopsies for reliable diagnosis of genital tuberculosis.

Prasad S, Singhal M, Negi SS, Gupta S, Singh S, Rawat DS, Rai A

IVF and Reproductive Biology Centre, Department of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, India.

OBJECTIVE: To evaluate the clinical utility of PCR compared with other available diagnostic modalities in prompt diagnosis of female genital tuberculo... Read More

Source: PubMed

  2011 Dec 1  

Update on the management of menometrorrhagia: new surgical approaches.

Fernandez H

Service Gynécologie Obstétrique, Hôpital Bicętre , Le Kremlin Bicętre , France.

Hysterectomy has traditionally been the definitive surgical approach for heavy menstrual bleeding. However, the more modern concept of 'save the uteru... Read More

Source: PubMed

Ceska Gynekol    

[Current classification of malignant tumours in gynecological oncology--part II].

Sehnal B, Driák D, Kmonícková E, Dvorská M, Hosová M, Citterbart K, Halaska M, Kolarík D

Gynekologicko-porodnická klinika, 1. LF UK a FN Na Bulovce, Praha.

Review of new staging systems for gynaecological cancers and their impact on prognosis and planning treatment.... Read More

Source: PubMed

Acta Dermatovenerol Alp Panonica Adriat    

Histopathology of cervical precursor lesions and cancer.

Lax S

Department of Pathology, Graz West General Hospital, Göstingerstrasse 22, A-8020 Graz, Austria. sigurd.lax@medunigraz.at, sigurd.lax@lkh-grazwest.at.

The most frequent types of cervical cancer are squamous-cell carcinoma and adenocarcinoma, which develop from the distinctive precursor lesions cervic... Read More

Source: PubMed

ScientificWorldJournal    

mRNA-Expression of ERa, ERß, and PR in Clonal Stem Cell Cultures Obtained from Human Endometrial Biopsies.

Schüring AN, Braun J, Wüllner S, Kiesel L, Götte M

Department of Gynecology and Obstetrics, University of Münster, Medical Center, 48149 Münster, Germany.

Background. Proliferation and differentiation of the endometrium are regulated by estrogen and progesterone. The enormous regenerative capacity of the... Read More

Source: PubMed

  2011 Nov 29  

Histopathology diagnosis in women who underwent a hysterectomy for a benign condition.

Saleh SS, Fram K

Department of Obstetrics and Gynaecology, Jordan University Hospital, PO Box 13046, Amman, 11942, Jordan, sssaleh@hotmail.com.

PURPOSE: To study the correlation between the preoperative clinical diagnosis and the final histopathology of hysterectomy speci... Read More

Source: PubMed

  2011 Nov 24  

Endometriosis-associated Serous Borderline Tumor and Endometrial Stromal Sarcoma of the Ovary: A Report of a Rare Lesion in an Infant.

Ho RS, Chan GC, Ha SY, Ip PP

Department of Pathology (R.S.L.H, P.P.C.I) Paediatrics and Adolescent Medicine (G.C.F.C, S.Y.H), The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR.

Endometriosis in infancy is most unusual, and associated tumors in this age group are exceptionally rare. We report a case of a serous borderline tumo... Read More

Source: PubMed


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Posted by:  Elaine54321(Guest)  Posted on: 05/17/2012
I had an endometrial biopsy about three months ago, straight after having my merina coil removed. I almost passed out with the pain and it felt like my insides had been cut out. I'm 55, not a sissy and have had three kids naturally. I couldn't have driven myself home I felt so dreadful. I had another appointment at the NHS clinic yesterday and explained that all my symptoms had settled and wasn't prepared to go through another procedure. The department head then came and told me that due to the results from the last biopsy I would have to have the procedure again to rule out cancer. Obviously I can't argue with that but am now absolutely terrified to go back and get it done. I can't believe that in this day and age anyone should have to suffer that sort of pain. I wasn't offered any sort of pain relief, no-one mentioned the Misoprostol [anyone know where I could get some in the UK?] Any advice greatly appreciated.



Posted by:  kerstinr5  Posted on: 05/11/2012
Hi! I just had my endometrial biopsy 20 minutes ago. I was very surprised how unpainful it was. I was very scarred and nervous and I wanted to back out of my appointment several times. I usually faint during medical proceedures but fortunately not with the endometrial biopsy. I took Misoprostol ( cervix dialation ) the night before. I also took 2 tablets of Ibuprofen pm the night before to be able to sleep. In the morning I took 4 tablets of 200 mg ibuprofen at 7 am. Then I took 1 tablet of percocet ( prescription painkiller that I had from my c- sections) and I took another 4 tablets of Ibuprofen 200 mg at noon. I took 2 more Ibuprofen 200 mg at 1:00 pm and 2 more percocet. That must have done the trick as I felt almost nothing. She used the clamps to hold the cervix and that felt like a little pinch nothing unbearable. Then she used what looked like big long cottonswaps to collect the sample. She said the cervix is plenty dialated due to the Misoprostol so that helped a lot. I felt a little swaping when she collected the samples but no pain. I felt a little pinch when she took the clamps off. That was it. When she entered the uterus with the cotton swaps she made me cough all the way so that I would not feel anything. I am very reliefed. Now I feel a little bit of cramping sitting at my desk but nothing real painful. So make sure the Dr. Office will give you a prescription for the Misoprostol 100 and a prescription painkiller as the ibuprofen alone might not have prevented any pain. It is not as bad as it sounds on the websites so head up you can do it!



Posted by:  weeze(Guest)  Posted on: 02/03/2012
HAD THIS DONE YESTERDAY...AND LETS JUST SAY...I WILL NEVER GET THIS DONE AGAIN....IT WAS ALMOST TO THE POINT OF UNBEARABLE...HAD IT NOT BEEN A RATHER QUICK PROCEDURE I COULD HAVE PASSED OUT OR HAD A SEIZURE FROM THIS UNDESCRIBABLE CRAMPING/TWISTING/WRENCHING PAIN...I DON'T KNOW WHO WOULD DO THIS TWICE?FEELS JUST LIKE WHAT IS HAPPENING...YOUR INSIDES ARE BEING YANKED OUT OF YOU!! LETS NOT SUGAR COAT IT LADIES...THATS EXACTLY WHATS HAPPENING!!!


Posted by:  BNIGHTBIRD  Posted on: 02/15/2012
I posted to this on Feb 2 2011. Please ladies, if you need to have this procedure again and live in the Long Island (NY) area, please contact me. I will give you the name of my doctor. She is absolutely wonderful. I know 2 other girls who had this procedure with her. They both had the same good experience. ( I would do it again in an instant)



Posted by:  boop2(Guest)  Posted on: 03/08/2012
In this day and age, there is no reason for anyone to have to be subjected to that kind of pain. They sedate for a colonoscopy, then they can sedate for a biopsy. My new Dr. told me I need one, but I said I would rather have a d and c with hysteroscopy under anesthesia. He said "ok". I hope you can recover from this trauma. No doctor should keep going with this procedure, if a patient is asking them to stop. Plus, if a woman is bleeding, a d and c will need to be done anyway, in most instances, so why not give the woman an option? Doesn't make sense. I would sue and I'm not normally someone who would say that.




Posted by:  mislead(Guest)  Posted on: 02/03/2012
I just had my endometrial biopsy done yesterday, and really I can tolerate some pain, BUT this was the worst PAIN ever!!! I don't understand why the doctor does not tell you that some people experience horrific pain and just give you the option to take some really, really, strong pain meds, or in my case I wish I was just "KNOCKED" out. I was given some xanax, Ibuprofen, and these pills to take [can't remember the name] to soften my cervic for the procedure since I have never had any kids and I am 47 yrs old.They couldn't even finish the biopsy because they had such a hard time getting through my cervic,,,that and I was convulsing on the table from all the pain.....With modern technology today WHY do we have to go through this when they have ways for us to not feel that??? They stopped the procedure, and had to roll me over to give me an injection of pain medicine so that I would stop shaking and convusling. As it is,,,looks like I am going to need a partial hysterectomy which is ok...at least I am knocked out for that! My advice....GET VERY STRONG PAIN MEDS! INSIST ON IT! It's YOUR body!!! and Your decision!



Posted by:  catsnhorses(Guest)  Posted on: 12/19/2011
I had a biopsy a week ago. I too felt like it was painful and got close to being unbearable. I stupidly didn't take any pain meds before hand. I wish I had taken a Xanax! How long did it take to get results? I'm very anxious. I'm 39, no kids yet, and hoping I don't need a hysterectomy.



Posted by:  veryworried4  Posted on: 12/09/2011
I am in my first trimester, carrying four babies.... My OB doctor wants to do a biopsy, I am high risk due to how many Babies and my age and other health problems i have and meds i was on.... What are my risk in loseing the babies if i get this done? Me and my husband are very worried....



Posted by:  rebbie1974(Guest)  Posted on: 10/30/2011
I had an endometrial biopsy on 10/4/2011 - and there was pain - more than I expected. But my worry now is that my last period was 9/26 - and nothing since the bleeding/spotting after the biopsy. I guess I was just wondering if this was normal? thanks



Posted by:  Beth44(Guest)  Posted on: 10/14/2011
I agree with all of you who said it was the most painful thing you have experienced. I had one done yesterday and was not at all prepared for how painful it would be. What made things worse was that she could not get the instrument through my cervix, so she tried shoving it through 5 times. By the 4th time I was sobbing and begged her to stop, but she wouldn't. She finally got through my cervix the 5th time. I felt like my insides were being stabbed and ripped apart. I was shaking and sobbing and felt in shock, but no one offered any help. I felt very violated and felt like I was butchered. I'm not sure if I should write to the doctor or call someone in the clinic, but I don't want anyone else to have to go through this. I am having a lot of cramping and some bleeding.


Posted by:  AandJ0718(Guest)  Posted on: 10/26/2011
I had one done on Monday afternoon, the pain was unbearable at times, my dr was very understanding and kept checking on my pain. I've given birth vaginally 2 times, have had my share of miscarriages, D and Cs, paps, ets, but this by far was the worst pain ever felt1 I took 600mg of ifuprofen 1 hr before the procedure and it did nothing. I had to take presecribed pain control because the cramping continues. I'm not bleeding but the cramps are just constant and strong. I'm the biggest baby when it comes to pain but my fiance was there so I was trying not to cry so he wouldn't freak out but it came to a point that i couldn't anymore. Poor thing didn't know what to do...he just kept wiping my tears and holding my hand.



Posted by:  sapphiresongbird(Guest)  Posted on: 05/21/2012
I AGREE WITH YOUR DESCRIPTION, I TOLD MY MOTHER AFTERWARDS THAT I FELT LIKE I WAS RAPED. IT WAS THAT BAD! :[




Posted by:  rinkydinky(Guest)  Posted on: 10/07/2011
I had my endometrial biopsy today and was told I would feel a 'funny sensation' by my doctor. I have had many miscarriages and a c' sec before so I know pain... but this was so painful, I ended up humiliating myself by screaming. Hours later, I'm having cramps and cringing and the sharp memory of the pain...'funny sensation' alright...as long as you like being stabbed.



Posted by:  mrs.d  Posted on: 03/29/2011
I recently had an endometrial biopsy; aside of pressure and a little discomfort, the procedure itself went fine with minimal cramping for about a day. However, about a week and a half out, I am now experiencing lower backache and some really uncomfortable cramping where they took the biopsies. My results came back hyperplasia and I have a pre-op with the doctor next week for a hysterectomy. I plan to discuss this with her if symptoms still occurring but I was wondering if anyone had experienced this, this far out from having the procedure done and/or if this is something I should be concerned with and have checked out sooner?




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