J Thorac Dis
Hedgehog signaling pathway: the must, the maybe and the unknown.
Zarogoulidis P, Zarampouka K, Huang H, Darwiche K, Huang Y, Sakkas A, Zarogoulidis K
Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;
Lung cancer treatment consists from the basic chemotherapeutic drugs (e.g., platinum analogues) and from pharmaceuticals targeting the different genom...
Carcinogenesis 2013 Apr 12
The Notch Signaling Pathway as a Mediator of Tumor Survival.
Capaccione KM, Pine SR
The Cancer Institute of New Jersey, Department of Medicine, UMDNJ/Robert Wood Johnson Medical School, New Brunswick NJ, 08901, USA.
The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the...
Assessment of statin-associated muscle toxicity in Japan: a cohort study conducted using claims database and laboratory information.
Chang CH, Kusama M, Ono S, Sugiyama Y, Orii T, Akazawa M
Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan.
To estimate the incidence of muscle toxicity in patients receiving statin therapy by examining study populations, drug exposure status and outcome def...
Intern Emerg Med 2013 Apr 13
Fluoropyrimidine toxicity in patients with dihydropyrimidine dehydrogenase splice site variant: the need for further revision of dose and schedule.
Magnani E, Farnetti E, Nicoli D, Casali B, Savoldi L, Focaccetti C, Boni C, Albini A, Banzi M
Department of Medical Oncology, Azienda Ospedaliera ASMN, IRCCS, 42123, Reggio Emilia, Italy.
Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in the metabolic catabolism of 5-fluorouracil (5-FU) and its derivatives (capecitabine and tegaf...
Lasers Med Sci 2013 Apr 13
Laser treatment of recurrent herpes labialis: a literature review.
de Paula Eduardo C, Aranha AC, Simões A, Bello-Silva MS, Ramalho KM, Esteves-Oliveira M, de Freitas PM, Marotti J, Tunér J
Special Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry of the University of São Paulo (USP), Av. Prof. Lineu Prestes, 2227, 05508-000, São Paulo, SP, Brazil, firstname.lastname@example.org.
Recurrent herpes labialis is a worldwide life-long oral health problem that remains unsolved. It affects approximately one third of the world populati...
Cancer Metastasis Rev. 2013 Apr 13
Targeting MAPK pathway in melanoma therapy.
Cheng Y, Zhang G, Li G
Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
New drugs targeting the mitogen-activated protein kinase (MAPK) pathway have generated striking clinical response in melanoma therapy. From the discov...
Chemoradiation of rectal cancer.
Arrazubi V, Suárez J, Novas P, Pérez-Hoyos MT, Vera R, Martínez Del Prado P
Hospital Universitario de Basurto, Bilbao, Spain - email@example.com.
The treatment of locally advanced rectal cancer is a challenge. Surgery, chemotherapy and radiotherapy comprise the multimodal therapy that is adminis...
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Two rapid ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) methods with common sample pretreatment for therapeutic drug monitoring of immunosuppressants compared to immunoassay.
Tszyrsznic W, Borowiec A, Pawlowska E, Jazwiec R, Zochowska D, Bartlomiejczyk I, Zegarska J, Paczek L, Dadlez M
Institute of Biochemistry and Biophysics Polish Academy of Sciences, 5a Pawinskiego Street, Warsaw, Poland; Department of Chemistry, Warsaw University of Technology, 3 Noakowskiego Street, Warsaw, Poland. Electronic address: firstname.lastname@example.org.
Therapeutic drug monitoring of immunosuppressive agents is a critical and essential part of patient therapy after organ transplantation. We have devel...
Biochim. Biophys. Acta 2013 Apr 10
AD-1, a novel ginsenoside derivative, shows anti-lung cancer activity via activation of p38 MAPK pathway and generation of reactive oxygen species.
Zhang LH, Jia YL, Lin XX, Zhang HQ, Dong XW, Zhao JM, Shen J, Shen HJ, Li FF, Yan XF, Li W, Zhao YQ, Xie QM
Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, Medical College of Zhejiang University, Hangzhou 310058, China; Medical and Pharmaceutical Institute, Medicine School of Yangzhou University, Yangzhou 225001, China.
BACKGROUND: Ginseng is a traditional Chinese herb that has been used for thousands of years. In the present study, effects and mechanisms of AD-1 were...
Life Sci. 2013 Apr 9
Cognitive Impairments and Cancer chemotherapy: Translational Research at a Crossroads.
WiltonLogic LLC, 101 Wilton Woods Lane, Media, PA 19063, USA. Electronic address: email@example.com.
Cancer chemotherapy is often associated with cognitive deficits which may remain after the treatment has ended. As more people survive cancer, concern...