Transl Stroke Res
Effect of Iron Chelators on Methemoglobin and Thrombin Preconditioning.
Chen-Roetling J, Sinanan J, Regan RF
Department of Emergency Medicine, Thomas Jefferson University, 1025 Walnut Street, College Building Room 813, Philadelphia, PA 19107, USA.
Cell loss immediately adjacent to an intracerebral hemorrhage may be mediated in part by the toxicities of extracellular hemoglobin (Hb) and thrombin....
J Clin Sleep Med
Restless legs syndrome as the presenting symptom of multiple myeloma.
Aricň D, Raggi A, Siragusa M, Zucconi M, Ferri R
Department of Neurology I.C.
We report a patient affected by restless legs syndrome as the presenting symptom of multiple myeloma, a hematologic malignancy characterized by clonal...
Eur J Inorg Chem
Triptycene-based Bis(benzimidazole) Carboxylate-Bridged Biomimetic Diiron(II) Complexes.
Li Y, Myae Soe CM, Wilson JJ, Tuang SL, Apfel UP, Lippard SJ
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
A triptycene-based bis(benzimidazole) ester ligand, L3, was designed to enhance the electron donating ability of the heterocyclic nitrogen atoms relat...
Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline.
Technion Rappaort Faculty of Medicine, Eve Topf and NPF Centers of Excellence for Neurodegenerative Diseases Haifa, Haifa 30196, Israel. ; Department of Systems Biology, Yonsei University, Seoul 120-749, Korea.
Present anti-PD and -AD drugs have limited symptomatic activity and devoid of neuroprotective and neurorestorative property that is needed for disease...
Cafestol to Tricalysiolide B and Oxidized Analogues: Biosynthetic and Derivatization Studies Using Non-heme Iron Catalyst Fe(PDP).
Bigi MA, Liu P, Zou L, Houk KN, White MC
Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, IL 61801, USA, Fax +1(217)2445943.
The tricalysiolides are a recently isolated class of diterpene natural products featuring the carbon backbone of the well-known coffee extract, cafest...
Nephrol. Dial. Transplant. 2013 Apr 12
Kidney Disease: Improving Global Outcomes guidelines on anaemia management in chronic kidney disease: a European Renal Best Practice position statement.
Locatelli F, Bárány P, Covic A, De Francisco A, Del Vecchio L, Goldsmith D, Hörl W, London G, Vanholder R, Van Biesen W
1Department of Nephrology, Dialysis and Transplantation, 'Alessandro Manzoni' Hospital, Lecco, Italy.
Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) group has produced comprehensive clinical practice guidelines for the management of an...
J. Biol. Chem. 2013 Apr 12
IOP1 is an external component of human CIA machinery and functions in MMS19-dependent CIA pathway.
Seki M, Takeda Y, Iwai K, Tanaka K
Osaka University, Japan;
The emerging link between iron metabolism and genome integrity is increasingly clear. Recent studies have revealed that MMS19 and cytosolic iron-sulfu...
J. Bacteriol. 2013 Apr 12
Analysis of novel iron-regulated, surface anchored, hemin-binding proteins in Corynebacterium diphtheriae.
Allen CE, Burgos JM, Schmitt MP
Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892.
C. diphtheriae utilizes hemin and hemoglobin (Hb) as iron sources during growth in iron depleted environments, and recent studies have shown that the ...
Haematologica 2013 Apr 12
Hematologic responses in patients with aplastic anemia treated with deferasirox: a post-hoc analysis from the EPIC study.
Lee JW, Yoon SS, Shen ZX, Ganser A, Hsu HC, El-Ali A, Habr D, Martin N, Porter J
The catholic University of Korea;
Reports are emerging of hematologic responses associated with iron chelation therapy; however, studies are limited in aplastic anemia patients. Defera...