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Klinefelter's Syndrome

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Klinefelter's Syndrome - Overview

Klinefelter's Syndrome is the most frequent sex chromosomal genetic disorder and is caused by the presence of an extra X chromosome

Klinefelter Syndrome (KS), like Turner's Syndrome, is a sex chromosomal disorder and was described and named after the physician who described it. While KS individuals have an extra X- chromosomes or 47 chromosomes, a person with Turner's lack a X chromosome and has a total of 45 chromosomes.

Klinefelter Syndrome (KS), was first described by Dr. Harry Klinefelter and his colleagues in 1942, while studying nine men with fertility problems and enlarged breasts. They found that the condition occurred only in males and was usually not identified until after puberty. It took another ten long years for Patricia Jacobs and J.A. Strong to demonstrate that the majority of males with KS have 47 chromosomes.

Klinefelter's Syndrome, which affects 1 in 500 to 1 in 1000 live births, is a sex chromosomal genetic disorder where the affected males have an extra X chromosome. These individuals are also referred to as 'males with XXY syndrome', or as 'XXY males'.This is not an inherited disorder.

Normal sexual development is seen in infancy and childhood. Although the onset of puberty is not delayed, the post-pubertal developments are inadequate in comparison to normal males. KS adolescents have low levels of confidence compared to other boys of the same age.

Although their educational achievements tend to be poor compared to their contemporaries, many KS patients show normal intelligence and function well in society. Most of them complete college and reach high positions professionally. These individuals may live their entire lives without the slightest doubt that they are in any way unusual.

Nine cases are presented of a syndrome characterized by gynecomastia, and small testes with aspermatogenesis but without a-leydigism. The follicle-stimulating hormone (FSH) excretion in the urine is increased to a degree comparable to that found in castrates…. These studies support the point of view that the testis produces two hormones;
a) androgen from the Leydig cells,
b) X-hormone (inhibin) from the tubules. Inhibin is analogous and probably very similar to estrin.
Harry Fitch Klinefelter, Edward C. Reifenstein Jr., Fuller Albright, 1942

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The enlarged breast in men is called gynocomasta. The doctors are not very shure why it happens, but imbalance in the testosterone level can be one reason others can be drug abuse etc. The only solution is Surgery. General surgeon can perform the surgery under local anesthesia[ means injecting the chest are with a numming agent] and you will be released out in the same day. Liposuction is another good solution where the surgeon will pull out the fats form the breast using a surgical needle with a pipe attached to a pump and you will be released in a few hours after dressing. You have to be lying flat on the bed for one week wearing a belt and then after opening the stitches you will be asked to not pull weight for a month or so after that you will leave a normal life. But before surgery get in touch with doctors of the ENDOCRINOLOGY department will ask you to preform some blood tests and some scans to identify the cause of your problem- I AM A FORMER GYNACOMASTIYA PATIENT
metro123 Saturday, January 24, 2015
I have Mosaic KS. My 1 year old daughter is genetically mine and was conceived naturally. Miracles do happen guys, keep faith.
Dgrizzle Wednesday, March 13, 2013
10n God that is hope. but where u taking testosterone before u had ur daughter
1989zz Saturday, September 7, 2013
Sorry, but this is a question rather than a comment. Can a person have their genetic profile tested to see if they may produce a child with klienfelters syndrome?
Graham.W Wednesday, January 2, 2013
Hello have you been told you have KS [Klinefelters symdrome]and are you on the hormone injections yet , once you start the course of injections, which i have every 3 months for life , this means you wont be able to have children , due to the treatment kills the sperm , im 42 now and cant have children . but miricals do happen so my doctor tells me . hope this is of some interest Carl
Carl42withKS Saturday, February 23, 2013
I have only recently learned of KS. I have a 17 y/o son who exhibits many of the physical characteristics. Please help me if you know of a specialist in the Houston area who can assist.
LastToKnow Tuesday, June 26, 2012
hy im digvijay singh from Rajasthan, INDIA. im 22 ye old ,i have just recently noticed that i m having some kind of breast development and my body is shaping into likely to girls ,im a student of, i want to make my life but this is giving me trouble,, what should i do and where should i go .. to avoid these symptoms.
djay Wednesday, May 30, 2012
dude did u get solution for this? i'm also suffering from the same plz help me too
sagar4006 Monday, June 25, 2012
hy im maynk sharma from INDIA. im 21 ye old ,i have just recently noticed that i m having some kind of breast development and my body is shaping into likely to girls ,im a student of msc, i want to make my life but this is giving me trouble,, what should i do and where should i go .. to avoid these symptoms.
mayankoo Monday, May 7, 2012
As a Klinefelter-adult [prognose when I was 53] I use now every 12 weeks a Testosteron injection of 'Nebido' from Bayer Pharma Germany in Europe. It's 1 ampule is 4ml liquid, 4ml is 1000mg Testosteron-undecanoat. I'm bedridden with CRPS (feet), AD(H)D, Esophagus Spasmes (Areopagus)..... And I cannot fall asleep, I sleep maybe 10-14 hours a week, the rest of the week I'm awake. So all other medication was nothing in bed. With the 'Sustanon'-injections (1ml=250mg) I had too many ups and downs and only on the highest level (in a period) I had a well feeling but that was for me too short. The 'Nebido' injections give me a steady/balanced feeling and is for me okay. The price for 3 ampules is: €562,74. I hope ypu can read my school/holiday-English well. From the Netherlands I say hello. Below each written message I write this signature: ~I'm open, honest and sincere to myself and to others....! ~
Eglefino Monday, October 17, 2011
I am looking for a clinical psychologist who deals with KS adolescence in central Illinois...If you know of a GOOD one please contact me at jnacke@consolidatednet. thank you!
jnacke Wednesday, July 27, 2011
I Mahendra Sinha my penis is small main jab exaited hota hun to mere whit watr nikal aata hai main 5to 10 minut main hi down hojata hun meri marrige ke 4year o gaye hain mere koi santan nahin hai maine apna sperm chek karvayo you sukranu nil hain mujhe koi sahi treatment batain
mahi123 Friday, March 25, 2011
I dont know if this will help anyone or maybe it will make me feel better. i had testicular cancer 10 years ago. found out that I have KS, have been taking medicine to help testosterone for sevral years. some side effects. i tend to get angry, short fuse,and can be a threat to others. but i have learned to deal with this. hopefully iam not the only one who feels like a genectic outcast.
brad51 Monday, February 14, 2011
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