Klinefelter's Syndrome

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Klinefelter's Syndrome - Overview

Klinefelter's Syndrome is the most frequent sex chromosomal genetic disorder and is caused by the presence of an extra X chromosome

Klinefelter Syndrome (KS), like Turner's Syndrome, is a sex chromosomal disorder and was described and named after the physician who described it. While KS individuals have an extra X- chromosomes or 47 chromosomes, a person with Turner's lack a X chromosome and has a total of 45 chromosomes.

Klinefelter Syndrome (KS), was first described by Dr. Harry Klinefelter and his colleagues in 1942, while studying nine men with fertility problems and enlarged breasts. They found that the condition occurred only in males and was usually not identified until after puberty. It took another ten long years for Patricia Jacobs and J.A. Strong to demonstrate that the majority of males with KS have 47 chromosomes.

Klinefelter's Syndrome, which affects 1 in 500 to 1 in 1000 live births, is a sex chromosomal genetic disorder where the affected males have an extra X chromosome. These individuals are also referred to as 'males with XXY syndrome', or as 'XXY males'.This is not an inherited disorder.

Normal sexual development is seen in infancy and childhood. Although the onset of puberty is not delayed, the post-pubertal developments are inadequate in comparison to normal males. KS adolescents have low levels of confidence compared to other boys of the same age.

Although their educational achievements tend to be poor compared to their contemporaries, many KS patients show normal intelligence and function well in society. Most of them complete college and reach high positions professionally. These individuals may live their entire lives without the slightest doubt that they are in any way unusual.

Nine cases are presented of a syndrome characterized by gynecomastia, and small testes with aspermatogenesis but without a-leydigism. The follicle-stimulating hormone (FSH) excretion in the urine is increased to a degree comparable to that found in castrates…. These studies support the point of view that the testis produces two hormones;
a) androgen from the Leydig cells,
b) X-hormone (inhibin) from the tubules. Inhibin is analogous and probably very similar to estrin.
Harry Fitch Klinefelter, Edward C. Reifenstein Jr., Fuller Albright, 1942

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metro123 Saturday, January 24, 2015

The enlarged breast in men is called gynocomasta. The doctors are not very shure why it happens, but imbalance in the testosterone level can be one reason others can be drug abuse etc. The only solution is Surgery. General surgeon can perform the surgery under local anesthesia[ means injecting the chest are with a numming agent] and you will be released out in the same day. Liposuction is another good solution where the surgeon will pull out the fats form the breast using a surgical needle with a pipe attached to a pump and you will be released in a few hours after dressing. You have to be lying flat on the bed for one week wearing a belt and then after opening the stitches you will be asked to not pull weight for a month or so after that you will leave a normal life. But before surgery get in touch with doctors of the ENDOCRINOLOGY department will ask you to preform some blood tests and some scans to identify the cause of your problem- I AM A FORMER GYNACOMASTIYA PATIENT

Dgrizzle Wednesday, March 13, 2013

I have Mosaic KS. My 1 year old daughter is genetically mine and was conceived naturally. Miracles do happen guys, keep faith.

1989zz Saturday, September 7, 2013

10n God that is hope. but where u taking testosterone before u had ur daughter

Graham.W Wednesday, January 2, 2013

Sorry, but this is a question rather than a comment. Can a person have their genetic profile tested to see if they may produce a child with klienfelters syndrome?

Carl42withKS Saturday, February 23, 2013

Hello have you been told you have KS [Klinefelters symdrome]and are you on the hormone injections yet , once you start the course of injections, which i have every 3 months for life , this means you wont be able to have children , due to the treatment kills the sperm , im 42 now and cant have children . but miricals do happen so my doctor tells me . hope this is of some interest Carl

LastToKnow Tuesday, June 26, 2012

I have only recently learned of KS. I have a 17 y/o son who exhibits many of the physical characteristics. Please help me if you know of a specialist in the Houston area who can assist.

djay Wednesday, May 30, 2012

hy im digvijay singh from Rajasthan, INDIA. im 22 ye old ,i have just recently noticed that i m having some kind of breast development and my body is shaping into likely to girls ,im a student of b.tech, i want to make my life but this is giving me trouble,, what should i do and where should i go .. to avoid these symptoms.

sagar4006 Monday, June 25, 2012

dude did u get solution for this? i'm also suffering from the same plz help me too

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