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Gilbert’s Syndrome
Drugs For Gilbert’s Syndrome
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Gilbert’s Syndrome | |
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Gilbert’s syndrome is a common, mild liver disease in which a liver enzyme required to process bilirubin is abnormal. Treatment is not necessary. Gilbert’s syndrome is a common, mild liver disease in which a liver enzyme required to process bilirubin (a chemical produced by the normal breakdown of red blood cells) is abnormal. It is a harmless inherited genetic condition found in up to five percent of the population. Gilbert’s syndrome is often discovered by accident in young adults by finding an elevated bilirubin level in blood. This raised bilirubin level usually fluctuates between 2 and 5 mg/dl and may increase with fasting and other stressos. The syndrome is often mistaken for chronic hepatitis or other liver diseases. Treatment is not necessary.  Gilbert's syndrome is also known as constitutional hepatic dysfunction, benign unconjugated bilirubinemia and familial nonhemolytic jaundice. Causes of Gilbert’s Syndrome Gilbert’s syndrome is the result of a mutation in a gene for the enzyme UGT1A. Metabolism of bilirubin requires enzymes called UGT glucuronosyl transferases, and UGT1A is one among these. The gene that codes for UGT1A is located on chromosome 2. A different type of mutation in the same gene is responsible for a more severe and dangerous disease called Crigler-Najjar syndrome. Gilbert’s syndrome is inherited in an autosomal recessive pattern, i.e. a copy of the defective gene from both parents is required for the child to develop the serious ailment. Many people carry one copy of the abnormal gene. Two abnormal copies are needed for Gilbert’s syndrome to develop. |
Latest Publication and Research on Gilbert’s Syndrome - Updated on 12/06/2011
Clinical profile, BRCA2 expression, and the androgen receptor CAG repeat region in Egyptian and moroccan male breast cancer patients. - Published by PubMed
Recurrent glioblastoma: a fresh look at current therapies and emerging novel approaches. - Published by PubMed
Ageing well: improving the management of patients with multiple chronic health problems. - Published by PubMed
Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application. - Published by PubMed
Anophthalmos, Microphthalmos, and Coloboma in the United Kingdom: Clinical Features, Results of Investigations, and Early Management. - Published by PubMed
Clinical profile, BRCA2 expression, and the androgen receptor CAG repeat region in Egyptian and moroccan male breast cancer patients. - Published by PubMed
Recurrent glioblastoma: a fresh look at current therapies and emerging novel approaches. - Published by PubMed
Ageing well: improving the management of patients with multiple chronic health problems. - Published by PubMed
Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application. - Published by PubMed
Anophthalmos, Microphthalmos, and Coloboma in the United Kingdom: Clinical Features, Results of Investigations, and Early Management. - Published by PubMed
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