Gilbertís syndrome is a common, mild liver disease in which a liver enzyme required to process bilirubin (a chemical produced by the normal breakdown of red blood cells) is abnormal. It is a harmless inherited genetic condition found in up to five percent of the population. Gilbertís syndrome is often discovered by accident in young adults by finding an elevated bilirubin level in blood. This raised bilirubin level usually fluctuates between 2 and 5 mg/dl and may increase with fasting and other stressos. The syndrome is often mistaken for chronic hepatitis or other liver diseases. Treatment is not necessary.
Gilbert's syndrome is also known as constitutional hepatic dysfunction, benign unconjugated bilirubinemia and familial nonhemolytic jaundice.
Causes of Gilbertís Syndrome
Gilbertís syndrome is the result of a mutation in a gene for the enzyme UGT1A. Metabolism of bilirubin requires enzymes called UGT glucuronosyl transferases, and UGT1A is one among these. The gene that codes for UGT1A is located on chromosome 2.
A different type of mutation in the same gene is responsible for a more severe and dangerous disease called Crigler-Najjar syndrome.
Gilbertís syndrome is inherited in an autosomal recessive pattern, i.e. a copy of the defective gene from both parents is required for the child to develop the serious ailment. Many people carry one copy of the abnormal gene. Two abnormal copies are needed for Gilbertís syndrome to develop.
Latest Publication and Research on Gilbertís SyndromeAdverse effects of health anxiety on management of a patient with benign paroxysmal positional vertigo, vestibular migraine and chronic subjective dizziness. - Published by PubMed
A Case of Hereditary Spherocytosis Coexisting with Gilbert's Syndrome. - Published by PubMed
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans. - Published by PubMed
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay. - Published by PubMed
Protection from age related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome. - Published by PubMed