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Genetics of Male Infertility - Y- Chromosome Microdeletions
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Genetics of Male Infertility
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Genetics of Male Infertility
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Y-Chromosome Microdeletions |
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Most of the microdeletions that cause azoospermia or oligospermia occur in the non-overlapping regions of the long arm of the Y-chromsome. These regions, also called azoospermia factor regions, are responsible for spermatogenesis. The loci are termed AZFa, AZFb and AZFc from proximal to distal Yq (Yq11.21-23 region). Several genes located in AZF regions which are found to be associated with spermatogenesis are viewed as “AZF candidate genes”. AZFa and candidate genes: The size of the AZFa region is estimated to be 1Mb. The frequency of deletions in AZFa is lower than that of both AZFb and AZFc. AZFb and candidate genes: AZFc and candidate genes: |
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