EPO has been used with some preliminary success in some cancers, principally cerebral gliomas. It has not proved useful for tardive dyskinesia, premenstrual syndrome or menopausal flushing. It may be indicated in some cases for atopic dermatitis, particularly to help with itching, as well as for uremic skin conditions in hemodialysis patients. It should probably not be used in efforts to enhance immunity as it may be immunosuppressive. EPO is approved in the United Kingdom as a pharmaceutical treatment for atopic dermatitis and mastalgia.