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Conn Syndrome
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Conn Syndrome / Primary Hyperaldosteronism
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Text 
 Conn’s syndrome was first described by the American endocrinologist Jerome W. Conn in 1955, in a patient who had an aldosterone-secreting adenoma. Presently, the term “primary hyperaldosteronism” is used to describe Conn syndrome and other associated conditions, such as adrenal hyperplasia. In a population with hypertension in the United States, prevalence for primary hyperaldosteronism, and specifically for Conn syndrome, is estimated to be around 0.05-2% and 0.03-1.2% respectively. The condition occurs twice as commonly in women as in men. It is mainly seen in those between 30-60 years of age. Primary hyperaldosteronism can be inherited in some people in an autosomal dominant fashion. It is caused by the increased secretion of the hormone aldosterone from the adrenal glands. Aldosterone acts on the kidneys resulting in an increase in sodium and lowering of potassium levels in the blood, and increases the alkalinity of the blood. Primary hyperaldosteronism has two major subtypes: (1) unilateral alderosterone producing adenoma or Conn syndrome (50-60% of all cases), and (2) bilateral adrenal hyperplasia (40-50% of all cases). In bilateral adrenal hyperplasia, aldosterone levels increase with changes in posture. |
Latest Publication and Research on Conn Syndrome - Updated on 04/18/2013.
Neonatal Bartter syndrome associated with ileal atresia and cystic fibrosis. - Published by PubMed
Adrenal incidentalomas: A collection of six interesting cases and brief review of literature. - Published by PubMed
Hormones other than aldosterone may contribute to hypertension in 3 different subtypes of primary aldosteronism. - Published by PubMed
Aldosterone Directly Affects Apelin Expression and Secretion in Adipocytes. - Published by PubMed
Adrenal Venous Sampling for Primary Hyperaldosteronism in Patients with Concurrent Chronic Kidney Disease. - Published by PubMed
Neonatal Bartter syndrome associated with ileal atresia and cystic fibrosis. - Published by PubMed
Adrenal incidentalomas: A collection of six interesting cases and brief review of literature. - Published by PubMed
Hormones other than aldosterone may contribute to hypertension in 3 different subtypes of primary aldosteronism. - Published by PubMed
Aldosterone Directly Affects Apelin Expression and Secretion in Adipocytes. - Published by PubMed
Adrenal Venous Sampling for Primary Hyperaldosteronism in Patients with Concurrent Chronic Kidney Disease. - Published by PubMed
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