Castration in males is a procedure by which the person loses the function of his testes, thereby resulting in loss of libido and infertility. In ancient India, castration was done on strong males to convert them into eunuchs, who were then posted to guard women’s quarters. Sexual offenders have been granted the punishment of castration in some countries.
Castration is done through two different procedures: In surgical castration, the testes are surgically removed. Thus, the effects of this type of castration are permanent. In medical or chemical castration, drugs are administered at regular intervals to reduce the levels of testosterone in the body, thereby reducing sexual drive and resulting in infertility. Thus, though the words ‘chemical castration’ may sound very scary, the actual procedure involves only administration of some medication to a person.
Castration has not only been done as a form of punishment or ritual, it also has a role in therapy. Chemical castration is commonly done for advanced prostate cancer, to keep the growth of the cancer cells in check.
Latest Publications and Research on Chemical CastrationOvercoming mutation-based resistance to antiandrogens with rational drug design. - Published by PubMed
Ericifolin: A Novel Antitumor Compound from Allspice that silences Androgen Receptor in Prostate Cancer. - Published by PubMed
Genetic Parameters for Androstenone and Skatole as indicators of Boar Taint and their relationship to Production and Litter Size Traits in Danish Landrace. - Published by PubMed
PPP2R2C loss promotes castration-resistant prostate cancer growth and is associated with increased prostate cancer-specific mortality. - Published by PubMed
Chemical restraint and injectable anesthesia of ruminants. - Published by PubMed