You may feel a sharp sting and a burning sensation when the anesthesia is injected to numb the skin over the biopsy site and into the covering of the bone. 

You may hear a soft crunching sound and feel pressure and pain when the biopsy needle enters the bone. The pain may be intense, but it usually lasts for a few seconds.

During an aspiration, you may feel a brief, shooting pain down your leg as the marrow fluid is taken. This pain should stop as soon as the sample is taken and the biopsy site is monitored for bleeding. 

You may need to stay in bed for 30 to 60 minutes after the procedure so the site can be monitored for bleeding and your bandage can be removed after 1 hour.

If you are given a sedative, avoid driving or other activities that require alertness until you are fully recovered.

You may feel some soreness at the biopsy site for several days and Ice packs are applied to the area, walking, and pain medication can be used to relieve the discomfort. However, the site may feel sore (like a bad bruise) for several days.

The site may bleed a small amount; ask your health professional how much drainage to expect.