Under normal conditions, our body resorts to its own mechanism to cope with bleeding through a process called hemostasis. During this process the blood vessels constrict to decrease blood flow and platelets in the blood accumulate to form a plug. This is then stabilized by a film of fibrin that forms a barrier. This barrier remains in place till the injury is fully healed.
The process of clot formation, involving a range of clotting factors, occurs sequentially in a coagulation ‘cascade’. The clot is dissolved (fibrinolysis) once the wound is healed.
In people with bleeding disorders, the clotting process is impaired and this results in spontaneous bleeding. If a component that aids in clotting is missing, deficient or is dysfunctional then it results in excessive bleeding.
Bleeding conditions do not have a permanent cure. They can, however, be managed.
Latest Publication and Research on Bleeding DisordersTotal Thyroidectomy for Multinodular Goiter. Possibility of Implementation in a District Hospital. - Published by PubMed
A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparins anticoagulant activity. - Published by PubMed
Procoagulant tissue factor-exposing vesicles in human seminal fluid. - Published by PubMed
Two cases of acquired haemophilia A associated with chronic myelomonocytic leukaemia. - Published by PubMed
Presentation, distribution pattern, and management of diverticular disease in a Nigerian tertiary hospital. - Published by PubMed